Effects of Fructus mume Extract on MAPK and NF-κB Signaling and the Resultant Improvement in the Cognitive Deficits Induced by Chronic Cerebral Hypoperfusion
Figure 4
F. mume reduced BCCAo-induced microglial activation in the hippocampus and the fimbria of hippocampus. (a) Representative photomicrograph of Iba-1 positive cells. (b) The number of Iba-1 positive cells was increased in the CA1 of BCCAo rats (*), but not in the BCCAo hippocampus treated with F. mume (#). No difference among groups was observed in the CA3 and DG. (c) Representative photomicrograph of OX-6 positive cells microglia in the fimbria of the hippocampus. (d) The number of OX-6 positive cells was increased in the fimbria of BCCAo rats (*), but not in the BCCAo fimbria treated with F. mume (#).
