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Evidence-Based Complementary and Alternative Medicine
Volume 2012, Article ID 452431, 8 pages
Research Article

Chemical Composition, Antioxidant, and Antimicrobial Activities of Lichen Umbilicaria cylindrica (L.) Delise (Umbilicariaceae)

1Department of Pharmacy, Medical Faculty, University of Kragujevac, 34 000 Kragujevac, Serbia
2Department of Biology and Ecology, Faculty of Sciences and Mathematics, University of Nis, 18 000 Nis, Serbia
3Faculty of Agronomy, University of Kragujevac, 32 000 Čačak, Serbia
4College of Applied Professional Studies, 17000 Vranje, Serbia

Received 30 May 2011; Accepted 29 June 2011

Academic Editor: Andreas Sandner-Kiesling

Copyright © 2012 Nedeljko T. Manojlovic et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The phytochemical analysis of methanol and chloroform extracts of Umbilicaria cylindrica was determined by HPLC-UV method. The predominant phenolic compound in both extracts was depsidone, salazinic acid (1). Besides salazinic acid, the tested extracts of U. cylindrica contain norstictic acid (2), methyl-β-orcinol carboxylate (3), ethyl haematommate (4), atranorin (5), and usnic acid (6), in different amounts and relations. The lichen extracts showed comparable and strong antioxidant activity, exhibited higher DPPH and hydroxyl radical scavengings, chelating activity, and inhibitory activity towards lipid peroxidation. The lichen extracts demonstrated important antimicrobial activity against eight strains with MIC values from 15.62 to 62.50 μg/mL. This is the first report of the detail chemical composition and antioxidant activity of the lichen Umbilicaria cylindrica, and the results suggest that this lichen can be used as a new source of the natural antioxidants and the substances with antimicrobial features.