Metabonomic Evaluation of ZHENG Differentiation and Treatment by Fuzhenghuayu Tablet in Hepatitis-B-Caused Cirrhosis

Table 1

Identification results and the changed trend of differential metabolites of hepatitis-B-caused Cirrhosis subjects compared to healthy group.

Number	Metabolites	RT (min)	VIP	Changing trend compared with HG
1	Butanoic acid	5.29	2.25	↑**
2	Propanedioic acid	5.98	1.81	↑**
3	Hexanedioic acid	6.03	1.97	↓ **
4	L-Alanine	8.06	2.28	↑**
5	Thiourea	9.75	1.73	↓ **
6	acrylic acid	12.91	1.55	↓ **
7	L-Proline	16.9	2.12	↑**
8	Methionine	17.8	1.57	↑**
9	Phenol	27.87	2.08	↑**
10	Benzoic acid	31.71	1.59	↓ **
11	Benzenamine	31.79	1.97	↑**
12	Tyrosine	32.49	1.75	↑**
13	1,4-Butanedioic acid	34.41	1.92	↑**
14	DL-Tryptophan	34.44	1.83	↑**
15	L-Lysine	34.75	2.11	↑**
16	Isothiourea	34.78	2.04	↑**
17	Benzyl alcohol	35.08	1.61	↑**
18	Indole	36.21	2.03	↑**
19	Propanoic acid	36.4	1.64	↑**
20	Hexanoic acid	36.71	2.26	↑**
21	n-Butylamine	36.78	1.88	↑**
22	Acetic acid	36.81	1.69	↑**
23	Pentanoic acid	36.89	1.64	↑**
24	Tyrosyl-cysteine methyl ester	37.37	2.04	↑**

The levels of differential metabolites were labeled with (↓) downregulated and (↑) upregulated (**𝑃<0.01).