Hesperetin, a Selective Phosphodiesterase 4 Inhibitor, Effectively Suppresses Ovalbumin-Induced Airway Hyperresponsiveness without Influencing Xylazine/Ketamine-Induced Anesthesia
Figure 1
Inhibition of PDE4 induced cAMP hydrolysis by hesperetin (a) and rolipram (b). Activities of PDE4 in the presence of various concentrations of hesperetin or rolipram, and the substrate (cAMP) were plotted according to a Lineweaver-Burk analysis. was determined from the equation of the apparent as a function of the inhibitor concentration (inset). Each value represents the mean ± SEM. The experimental number for hesperetin, and rolipram was 4 and 5, respectively.
