Hesperetin, a Selective Phosphodiesterase 4 Inhibitor, Effectively Suppresses Ovalbumin-Induced Airway Hyperresponsiveness without Influencing Xylazine/Ketamine-Induced Anesthesia

Figure 4

Effects of hesperetin (3 ~ 30 μmol/kg, i.p.) on total IgE (a, c) and ovalbumin-specific IgE (b, d) levels in bronchial alveolar lavage fluid (a, b) and serum (c, d) of sensitized mice which had received aerosolized methacholine (6.25 ~ 50 mg/mL) 2 days after primary allergen challenge. ^#𝑃<0.05, ^##𝑃<0.01 and ^###𝑃<0.001, compared to the nonchallenged group. *𝑃<0.05, **𝑃<0.01 and ***𝑃<0.001, compared to the control (vehicle) group. Each value represents the mean ± SEM. The number of mice in each group was 10.

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(b)

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