Evidence-Based Complementary and Alternative Medicine / 2012 / Article / Fig 6

Research Article

Acupuncture Alleviates Colorectal Hypersensitivity and Correlates with the Regulatory Mechanism of TrpV1 and p-ERK

Figure 6

EA blunts zymosan-induced ERK1and ERK2 activation. ERK1 and ERK2 activation is presented by phosph-ERK1 and ERK2 versus their related total ERK1 and ERK2. ERK1 and ERK2 activation is slightly induced by EA in group , while it is dramatically induced by zymosan injection. Zymosan-induced ERK1 and ERK2 activation is obviously compromised by EA in colorectum ( ), spinal cord ( ), and hypothalamus ( ). EA in alleviating hypersensitivity is probably associated with external signaling (p-ERK1/2: #9109, cell signaling, 42/44 KD, delusion: 1 : 2000; ERK1/2: #4695, cell signaling, 42/44 KD, delusion: 1 : 2000).
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