Acupuncture Alleviates Colorectal Hypersensitivity and Correlates with the Regulatory Mechanism of TrpV1 and p-ERK
EA blunts zymosan-induced ERK1and ERK2 activation. ERK1 and ERK2 activation is presented by phosph-ERK1 and ERK2 versus their related total ERK1 and ERK2. ERK1 and ERK2 activation is slightly induced by EA in group , while it is dramatically induced by zymosan injection. Zymosan-induced ERK1 and ERK2 activation is obviously compromised by EA in colorectum (), spinal cord (), and hypothalamus (). EA in alleviating hypersensitivity is probably associated with external signaling (p-ERK1/2: #9109, cell signaling, 42/44 KD, delusion: 1 : 2000; ERK1/2: #4695, cell signaling, 42/44 KD, delusion: 1 : 2000).
Article of the Year Award: Outstanding research contributions of 2020, as selected by our Chief Editors. Read the winning articles.