Dual Roles of Quercetin in Platelets: Phosphoinositide-3-Kinase and MAP Kinases Inhibition, and cAMP-Dependent Vasodilator-Stimulated Phosphoprotein Stimulation

Figure 3

Quercetin attenuates fibrinogen binding to integrin 𝛼_IIb𝛽₃. Fibrinogen binding to integrin 𝛼_IIb𝛽₃ in platelets pre-treated with quercetin and stimulated by collagen (2.5 μg/mL) together with Alexa Fluor 488-human fibrinogen (200 μg mL⁻¹) followed by incubation at 37°C for 15 min. (a) Tracings are representatives of 4 independent experiments. (b) Bar graph represents summary of quercetin effects on fibrinogen binding. *𝑃<0.05, **𝑃<0.01.

(a)

(b)