Gallic Acid Enriched Fraction of Phyllanthus emblica Potentiates Indomethacin-Induced Gastric Ulcer Healing via e-NOS-Dependent Pathway

Figure 1

Healing capacities of GAE under various treatment regimes against indomethacin-induced acute gastric mucosal injury in mice. Ulceration in the mice was induced by indomethacin (18 mg /kg, single dose, p.o.). Treatment was carried out with GAE (3, 4, 5, 6, 7 mg/kg, single dose daily up to 7 days, p. o.) after indomethacin administration. The section of mice stomachs were dissected on the 1st, 3rd, and 7th days of ulceration, 4 h after the last dose of the test sample, and the damage scores of different mice groups were measured. The values are mean ± S.E. of four independent experiments, each with 8 mice/group. *𝑃<0.001, compared to 1st day ulcerated mice; **𝑃<0.01, ***𝑃<0.001, compared to untreated mice of the same day.