Evidence-Based Complementary and Alternative Medicine / 2012 / Article / Fig 3

Research Article

Gallic Acid Enriched Fraction of Phyllanthus emblica Potentiates Indomethacin-Induced Gastric Ulcer Healing via e-NOS-Dependent Pathway

Figure 3

Reduction of the mucosal MPO activity in ulcerated mice by GAE. (a) under various treatment regimes; (b) optimized treatment regime. Ulceration in the mice was induced by indomethacin (18 mg/kg, single dose, p.o.). Treatment was carried out with different doses of GAE upto 7 days after indomethacin (18 mg/kg, single dose, p.o.) administration. The section of mice stomachs were dissected on the 1st, 3rd, and 7th days of ulceration, 4 h after the last dose of the test sample, and the MPO activities of different groups of mice were measured. Omeprazole (3 mg/kg × 3 days, p. o.) was used as the positive control. The values are mean ± S.E. of four independent experiments, each with 8 mice/group. * 𝑃 < 0 . 0 0 1 , compared to 1st day ulcerated mice; ** 𝑃 < 0 . 0 1 , *** 𝑃 < 0 . 0 0 1 , compared to untreated mice of the same day. # 𝑃 < 0 . 0 0 1 , compared to 3rd day normal mice; $ 𝑃 < 0 . 0 0 1 , compared to 3rd day untreated mice.

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