Gallic Acid Enriched Fraction of Phyllanthus emblica Potentiates Indomethacin-Induced Gastric Ulcer Healing via e-NOS-Dependent Pathway

Figure 8

Effect of NOS inhibitors on the healing activity of GAE in indomethacin-induced ulcerated mice. (a) damage score, (b) MPO activity, (c) von Willebrand Factor VIII, (d) NO level. Ulceration in the mice was induced by indomethacin (18 mg /kg, single dose, p.o.). After ulcer induction, treatment was carried out with GAE (5 mg/kg, single dose daily, p. o.) alone or in conjunction with L-NAME (15 mg/kg, once daily) or L-NIL (3 mg/kg, twice daily) for 3 days. The parameters of the ulcerated untreated and treated mice were measured. *𝑃<0.001 compared to normal mice; **𝑃<0.01, compared to GAE-treatment.

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