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Evidence-Based Complementary and Alternative Medicine
Volume 2012, Article ID 487380, 13 pages
http://dx.doi.org/10.1155/2012/487380
Research Article

Gallic Acid Enriched Fraction of Phyllanthus emblica Potentiates Indomethacin-Induced Gastric Ulcer Healing via e-NOS-Dependent Pathway

1Department of Biochemistry, University College of Medicine, I.P.G.M.E&R, 244B A.J.C. Bose Road, West Bengal, Kolkata 700020, India
2Central Research Laboratory, Department of Biochemistry, KPC Medical College and Hospital, 1F Raja S.C. Mullick Road, Jadavpur, West Bengal, Kolkata 700032, India
3Department of Pharmaceutical Chemistry, Central Drugs Laboratory, 3 Kyd Street, Kolkata-700016, India
4Bio-Organic Division, Bhabha Atomic Research Centre, Mumbai 400085, India

Received 31 March 2012; Revised 8 July 2012; Accepted 10 July 2012

Academic Editor: José Luis Ríos

Copyright © 2012 Ananya Chatterjee et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. K. H. Khan, “Roles of emblica officinalis in medicine—a review,” Botany Research International, vol. 2, no. 4, pp. 218–228, 2009. View at Google Scholar
  2. Anonymous, “Case study on Amla-related patent, technology information,” Forecasting & Assessment Council (TIFAC) Bulletin, vol. 7, pp. 6–6, 2001. View at Google Scholar
  3. Y.-Y. Soong and P. J. Barlow, “Quantification of gallic acid and ellagic acid from longan (Dimocarpus longan Lour.) seed and mango (Mangifera indica L.) kernel and their effects on antioxidant activity,” Food Chemistry, vol. 97, no. 3, pp. 524–530, 2006. View at Publisher · View at Google Scholar · View at Scopus
  4. J. M. Gentile, S. Rahimi, J. Zwiesler, G. J. Gentile, and L. R. Ferguson, “Effect of selected antimutagens on the genotoxicity of antitumor agents,” Mutation Research, vol. 402, no. 1-2, pp. 289–298, 1998. View at Publisher · View at Google Scholar · View at Scopus
  5. M. A. Indap, S. Radhika, L. Motiwale, and K. V. K. Rao, “Anticancer activity of phenolic antioxidants against breast cancer cells and a spontaneous mammary tumor,” Indian Journal of Pharmaceutical Sciences, vol. 68, no. 4, pp. 470–474, 2006. View at Google Scholar · View at Scopus
  6. J. M. Kratz, C. R. Andrighetti-Fröhner, P. C. Leal et al., “Evaluation of anti-HSV-2 activity of gallic acid and pentyl gallate,” Biological and Pharmaceutical Bulletin, vol. 31, no. 5, pp. 903–907, 2008. View at Publisher · View at Google Scholar · View at Scopus
  7. P. Brooks, P. Emery, J. F. Evans et al., “Interpreting the clinical significance of the differential inhibition of cyclooxygenase-1 and cyclooxygenase-2,” Rheumatology, vol. 38, no. 8, pp. 779–788, 1999. View at Google Scholar · View at Scopus
  8. P. A. Gladding, M. W. I. Webster, H. B. Farrell, I. S. L. Zeng, R. Park, and N. Ruijne, “The antiplatelet effect of six non-steroidal anti-inflammatory drugs and their pharmacodynamic interaction with aspirin in healthy volunteers,” American Journal of Cardiology, vol. 101, no. 7, pp. 1060–1063, 2008. View at Publisher · View at Google Scholar · View at Scopus
  9. G. A. Piazza, A. B. Keeton, H. N. Tinsley et al., “NSAIDs: old drugs reveal new anticancer targets,” Pharmaceuticals, vol. 3, no. 5, pp. 1652–1667, 2010. View at Publisher · View at Google Scholar · View at Scopus
  10. A. Lanas, M. A. Perez-Aisa, F. Feu et al., “A nationwide study of mortality associated with hospital admission due to severe gastrointestinal events and those associated with nonsteroidal antiinflammatory drug use,” American Journal of Gastroenterology, vol. 100, no. 8, pp. 1685–1693, 2005. View at Publisher · View at Google Scholar · View at Scopus
  11. A. S. Tarnawski and M. K. Jones, “Inhibition of angiogenesis by NSAIDs: molecular mechanisms and clinical implications,” Journal of Molecular Medicine, vol. 81, no. 10, pp. 627–636, 2003. View at Publisher · View at Google Scholar · View at Scopus
  12. F. K. L. Chan, “Primer: managing NSAID-induced ulcer complications—balancing gastrointestinal and cardiovascular risks,” Nature Clinical Practice Gastroenterology and Hepatology, vol. 3, no. 10, pp. 563–573, 2006. View at Publisher · View at Google Scholar · View at Scopus
  13. J. I. Isenberg, K. R. McQuaid, L. Laine, and W. Rubin, “Acid-peptic disorders,” in Textbook of Gastroenterology, T. Yamada, D. H. Alpers, C. Owyng, D. W. Powell, and F. E. Silverstein, Eds., vol. 1, p. 1253, 1991. View at Google Scholar
  14. A. Tarnawski, I. L. Szabo, S. S. Husain, and B. Soreghan, “Regeneration of gastric mucosa during ulcer healing is triggered by growth factors and signal transduction pathways,” Journal of Physiology Paris, vol. 95, no. 1-6, pp. 337–344, 2001. View at Publisher · View at Google Scholar · View at Scopus
  15. A. Chatterjee, S. Chattopadhyay, and S. K. Bandyopadhyay, “Biphasic effect of Phyllanthus emblica L. extract on NSAID-induced ulcer: an antioxidative trail weaved with immunomodulatory effect,” Evidence-Based Complementary and Alternative Medicine, vol. 2011, Article ID 146808, 13 pages, 2011. View at Publisher · View at Google Scholar · View at Scopus
  16. S. Bhattacharya, S. Chatterjee, A. Bauri et al., “Immunopharmacological basis of the healing of indomethacin-induced gastric mucosal damage in rats by the constituents of Phyllanthus emblica,” Current Science, vol. 93, no. 1, pp. 47–53, 2007. View at Google Scholar · View at Scopus
  17. M. K. Jones, H. Wang, B. M. Peskar et al., “Inhibition of angiogenesis by nonsteroidal anti-inflammatory drugs: insight into mechanisms and implications for cancer growth and ulcer healing,” Nature Medicine, vol. 5, no. 12, pp. 1418–1423, 1999. View at Publisher · View at Google Scholar · View at Scopus
  18. J. Folkman and P. A. D'Amore, “Blood vessel formation: what is its molecular basis?” Cell, vol. 87, no. 7, pp. 1153–1155, 1996. View at Publisher · View at Google Scholar · View at Scopus
  19. L. Ma and J. L. Wallace, “Endothelial nitric oxide synthase modulates gastric ulcer healing in rats,” American Journal of Physiology, vol. 279, no. 2, pp. G341–G346, 2000. View at Google Scholar · View at Scopus
  20. D. Banerjee, B. Maity, A. K. Bauri, S. K. Bandyopadhyay, and S. Chattopadhyay, “Gastroprotective properties of Myristica malabarica against indometacin-induced stomach ulceration: a mechanistic exploration,” Journal of Pharmacy and Pharmacology, vol. 59, no. 11, pp. 1555–1565, 2007. View at Publisher · View at Google Scholar · View at Scopus
  21. D. Banerjee, A. K. Bauri, R. K. Guha, S. K. Bandyopadhyay, and S. Chattopadhyay, “Healing properties of malabaricone B and malabaricone C, against indomethacin-induced gastric ulceration and mechanism of action,” European Journal of Pharmacology, vol. 578, no. 2-3, pp. 300–312, 2008. View at Publisher · View at Google Scholar · View at Scopus
  22. D. Dokmeci, M. Akpolat, N. Aydogu, L. Doganay, and F. N. Turan, “L-Carnitine inhibits ethanol-induced gastric mucosal injury in rats,” Pharmacological Reports, vol. 57, pp. 481–488, 2005. View at Google Scholar
  23. K. Suzuki, H. Ota, S. Sasagawa, T. Sakatani, and T. Fujikura, “Assay method for myeloperoxidase in human polymorphonuclear leukocytes,” Analytical Biochemistry, vol. 132, pp. 345–352, 1983. View at Google Scholar
  24. M. M. Bradford, “A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding,” Analytical Biochemistry, vol. 72, pp. 248–254, 1976. View at Publisher · View at Google Scholar
  25. P. Guha, A. Dey, A. Chatterjee, S. Chattopadhyay, and S. K. Bandyopadhyay, “Pro-ulcer effects of resveratrol in mice with indomethacin-induced gastric ulcers are reversed by L-arginine,” British Journal of Pharmacology, vol. 159, pp. 726–734, 2010. View at Google Scholar
  26. S. Fiorucci, E. Antonelli, and A. Morelli, “Mechanism of non-steroidal anti-inflammatory drug-gastropathy,” Digestive and Liver Disease, vol. 33, no. 2, pp. S35–S43, 2001. View at Publisher · View at Google Scholar · View at Scopus
  27. L. Osborn, “Leukocyte adhesion to endothelium in inflammation,” Cell, vol. 62, no. 1, pp. 3–6, 1990. View at Publisher · View at Google Scholar · View at Scopus
  28. R. Langenbach, S. G. Morham, H. F. Tiano et al., “Prostaglandin synthase 1 gene disruption in mice reduces arachidonic acid- induced inflammation and indomethacin-induced gastric ulceration,” Cell, vol. 83, no. 3, pp. 483–492, 1995. View at Google Scholar · View at Scopus
  29. I. Tegeder, J. Pfeilschifter, and G. Geisslinger, “Cyclooxygenase-independent actions of cyclooxygenase inhibitors,” FASEB Journal, vol. 15, no. 12, pp. 2057–2072, 2001. View at Publisher · View at Google Scholar · View at Scopus
  30. M. H. L. P. Souza, H. Paula Lemos, R. B. Oliveira, and F. Q. Cunha, “Gastric damage and granulocyte infiltration induced by indomethacin in tumour factor 1 (TNF-R1) or inducible nitric oxide synthase (iNOS) deficient mice,” Gut, vol. 53, no. 6, pp. 791–796, 2004. View at Publisher · View at Google Scholar · View at Scopus
  31. J. E. Krawisz, P. Sharon, and W. F. Stenson, “Quantitative assay for acute intestinal inflammation based on myeloperoxidase activity. Assessment of inflammation in rat and hamster models,” Gastroenterology, vol. 87, no. 6, pp. 1344–1350, 1984. View at Google Scholar · View at Scopus
  32. J. L. Wallace, C. M. Keenan, and D. N. Granger, “Gastric ulceration induced by nonsteroidal anti-inflammatory drugs is a neutrophil-dependent process,” American Journal of Physiology, vol. 259, no. 3, pp. G462–G467, 1990. View at Google Scholar · View at Scopus
  33. H. Fujita, S. Takahashi, and S. Okabe, “Mechanism by which indomethacin delays the healing of acetic acid- induced ulcers in rats. Role of neutrophil antichemotactic and chemotactic activities,” Journal of Physiology and Pharmacology, vol. 49, no. 1, pp. 71–82, 1998. View at Google Scholar · View at Scopus
  34. N. Shimizu, T. Watanabe, T. Arakawa, Y. Fujiwara, K. Higuchi, and T. Kuroki, “Pentoxifylline accelerates gastric ulcer healing in rats: roles of tumor necrosis factor alpha and neutrophils during the early phase of ulcer healing,” Digestion, vol. 61, no. 3, pp. 157–164, 2000. View at Google Scholar · View at Scopus
  35. Y. Suzuki, M. Ishihara, T. Segami, and M. Ito, “Anti-ulcer effects of antioxidants, quercetin, α-tocopherol, nifedipine and tetracycline in rats,” Japanese Journal of Pharmacology, vol. 78, no. 4, pp. 435–441, 1998. View at Publisher · View at Google Scholar · View at Scopus
  36. C. F. Bou-Abboud, H. Wayland, G. Paulsen, and P. H. Guth, “Microcirculatory stasis precedes tissue necrosis in ethanol-induced gastric mucosal injury in the rat,” Digestive Diseases and Sciences, vol. 33, no. 7, pp. 872–877, 1988. View at Google Scholar · View at Scopus
  37. Y. Tsukimi, C. Nozue, and S. Okabe, “Effects of leminoprazole, omeprazole and sucralfate on indomethacin-induced delayed healing of kissing gastric ulcers in rats,” Journal of Gastroenterology and Hepatology, vol. 11, no. 4, pp. 335–340, 1996. View at Google Scholar · View at Scopus
  38. R. J. Gryglewski, A. Szczeklik, and M. Wandzilak, “The effect of six prostaglandins, prostacyclin and iloprost on generation of superoxide anions by human polymorphonuclear leukocytes stimulated by zymosan or formyl-methionyl-leucyl-phenylalanine,” Biochemistry Pharmacology, vol. 36, pp. 4209–4213, 1987. View at Publisher · View at Google Scholar
  39. J. R. Whittle, “Nitric oxide in gastrointestinal physiology and pathology,” in The Physiology of the Gastrointestinal Tract, L. R. Johnson, Ed., pp. 267–294, Raven, New York, NY, USA, 1994. View at Google Scholar
  40. M. Ziche, L. Morbidelli, E. Masini et al., “Nitric oxide mediates angiogenesis in vivo and endothelial cell growth and migration in vitro promoted by substance P,” Journal of Clinical Investigation, vol. 94, no. 5, pp. 2036–2044, 1994. View at Google Scholar · View at Scopus
  41. J. Piotrowski, A. Slomiany, and B. L. Slomiany, “Activation of apoptotic caspase-3 and nitric oxide synthase-2 in gastric mucosal injury induced by indomethacin,” Scandinavian Journal of Gastroenterology, vol. 34, no. 2, pp. 129–134, 1999. View at Google Scholar · View at Scopus
  42. J. Morton, B. Coles, K. Wright et al., “Circulating neutrophils maintain physiological blood pressure by suppressing bacteria and IFNγ-dependent iNOS expression in the vasculature of healthy mice,” Blood, vol. 111, no. 10, pp. 5187–5194, 2008. View at Publisher · View at Google Scholar · View at Scopus
  43. J. C. Luo, V. Y. Shin, E. S. L. Liu et al., “Non-ulcerogenic dose of dexamethasone delays gastric ulcer healing in rats,” Journal of Pharmacology and Experimental Therapeutics, vol. 307, no. 2, pp. 692–698, 2003. View at Publisher · View at Google Scholar · View at Scopus
  44. J. Folkman and Y. Shin, “Angiogenesis,” Journal of Biological Chemistry, vol. 267, pp. 10931–10934, 1992. View at Google Scholar
  45. W. Risau, “Mechanisms of angiogenesis,” Nature, vol. 386, pp. 671–673, 1997. View at Publisher · View at Google Scholar
  46. M. Takahashia, K. Oguraa, S. Maedaa et al., “Promoters of epithelialization induce expression of vascular endothelial growth factor in human gastric epithelial cells in primary culture,” FEBS Letter, vol. 418, pp. 115–118, 1997. View at Google Scholar
  47. T. Brzozowski, P. C. Konturek, S. J. Konturek et al., “Involvement of cyclooxygenase (COX)-2 products in acceleration of ulcer healing by gastrin and hepatocyte growth factor,” Journal of Physiology and Pharmacology, vol. 51, no. 4, pp. 751–773, 2000. View at Google Scholar · View at Scopus