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Evidence-Based Complementary and Alternative Medicine
Volume 2012, Article ID 487380, 13 pages
Research Article

Gallic Acid Enriched Fraction of Phyllanthus emblica Potentiates Indomethacin-Induced Gastric Ulcer Healing via e-NOS-Dependent Pathway

1Department of Biochemistry, University College of Medicine, I.P.G.M.E&R, 244B A.J.C. Bose Road, West Bengal, Kolkata 700020, India
2Central Research Laboratory, Department of Biochemistry, KPC Medical College and Hospital, 1F Raja S.C. Mullick Road, Jadavpur, West Bengal, Kolkata 700032, India
3Department of Pharmaceutical Chemistry, Central Drugs Laboratory, 3 Kyd Street, Kolkata-700016, India
4Bio-Organic Division, Bhabha Atomic Research Centre, Mumbai 400085, India

Received 31 March 2012; Revised 8 July 2012; Accepted 10 July 2012

Academic Editor: José Luis Ríos

Copyright © 2012 Ananya Chatterjee et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Supplementary Figure 1: Effect of GAE on total antioxidant status (A) and lipid peroxidation (B) in indomethacininduced ulcerated mice. Ulceration in the mice was induced by indomethacin (18 mg/kg, single dose). Treatment was carried out for 3 days with GAE (5 mg/kg, daily) or omeprazole (3 mg/kg) after ulcer induction.

Supplementary Figure 2: Effect of L-NAME in indomethacin -induced ulcerated mice. A: damage score, B: MPO activity, C: von Willebrand Factor VIII, D: NO level. Ulceration in the mice was induced by indomethacin (18 mg/kg, single dose). After ulcer induction, treatment was carried out with L-NAME (15 mg/kg, once daily) for 3 days.

  1. Supplementary Figures