Effects and Interaction of Icariin, Curculigoside, and Berberine in Er-Xian Decoction, a Traditional Chinese Medicinal Formula, on Osteoclastic Bone Resorption

Figure 1

Effects of I, B, C, and their combination on ovariectomized osteoporotic mice. Ovariectomized mice were administered with I (40 mg/kg), B (120 mg/kg), C (20 mg/kg), and their combination (I 40 mg/kg + C 20 mg/kg + B 120 mg/kg) for 12 weeks. Then, the uterine and body weight were weighed, the serum biochemical parameters were assayed. (a) uterine weight; (b) body weight; (c) ALP activity; (d) OPG content; (e) TRAP activity; (f) DPD/creatine. Data were presented as mean ± standard deviation, (𝑛=10). ^∗𝑃<0.05, and ^∗∗𝑃<0.01, ^∗∗∗𝑃<0.001 compared with OVX control.

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