Anti-Inflammatory Activities of a Chinese Herbal Formula IBS-20 In Vitro and In Vivo

Figure 9

Administration of IBS-20 suppresses the up-regulation of pro-inflammatory cytokine expression in the inflamed colon in vivo. Mice received intrarectal instillation of TNBS (2 mg/mouse in 40% ethanol) to induce colonic inflammation. IBS-20 extracts were given to mice daily via gavage. Mice were euthanized at day 7 after TNBS, and the colon was collected for mRNA expression of cytokines by qPCR. Results on the expression of IFNγ (a) and IL-12p40 (b) were shown. *𝑃<0.05 versus VEH; ^ϕ𝑃<0.05 versus IBS-20; 𝑛=5 for each group.

(a)

(b)