Assessment of Anticholinesterase Activity of Gelidiella acerosa: Implications for Its Therapeutic Potential against Alzheimer’s Disease

Table 2

Acetylcholinesterase inhibitory activity of different solvent extracts of Gelidiella acerosa.

S. no.	Solvent extract	% of inhibition ± S.D^a					IC50 (μg/mL)
		97.56 μg/mL	195.12 μg/mL	292.68 μg/mL	390.24 μg/mL	487.80 μg/mL
1	Donepezil	98.05 ± 0.23	98.05 ± 0.12	98.05 ± 0.30	98.39 ± 0.34	98.26 ± 0.23**	5.0985 ± 0.0046
2	Petroleum ether	9.95 ± 0.65	21.93 ± 2.49	29.20 ± 1.42	36.31 ± 1.18	41.36 ± 1.68	Nil
3	Hexane	NI^b	NI^b	NI^b	NI^b	NI^b	Nil
4	Benzene	14 ± 1.5	40 ± 3.05	40 ± 8.08	46 ± 3.46	54.18 ± 5.65**	434.61 ± 26.53
5	Dichloromethane	NI^b	NI^b	NI^b	1.99 ± 0.05	4.34 ± 0.29	Nil
6	Chloroform	26.28 ± 0.95	30.21 ± 0.36	33.44 ± 0.81	35.51 ± 0.67	37.60 ± 1.17	Nil
7	Ethyl acetate	39.28 ± 2.02	42.85 ± 0.68	46.42 ± 0.68	50 ± 0.68	53.57 ± 9.49*	444.44 ± 11.63
8	Acetone	0.19 ± 0.; 33	15.88 ± 1.45	31.51 ± 2.07	36.84 ± 0.21	45.92 ± 0.67	Nil
9	Methanol	9.8 ± 0.84	9.95 ± 0.34	10.02 ± 0.55	12.37 ± 3.40	14.82 ± 1.70	Nil
10	Water	NI^b	NI^b	NI^b	NI^b	6 ± 0.001	Nil

^aResults were expressed as mean ± SD (𝑛 = 3).
^bNI: no inhibition.
* 𝑃 < 0.05.
** 𝑃 < 0.01.