Assessment of Anticholinesterase Activity of Gelidiella acerosa: Implications for Its Therapeutic Potential against Alzheimer’s Disease

Table 3

Butyrylcholinesterase inhibitory activities of different solvent extracts of Gelidiella acerosa.

S. no.	Solvent extract	% of inhibition ± S.D^a					IC50 (μg/mL)
		97.56 μg/mL	195.12 μg/mL	292.68 μg/mL	390.24 μg/mL	487.80 μg/mL
1	Donepezil	67.71 ± 1.09	85.61 ± 8.50	85.96 ± 1.84	96.65 ± 2.64	91.57 ± 2.41**	7.266 ± 0.0065
2	Petroleum ether	22.17 ± 3.96	24.46 ± 2.28	25.22 ± 4.76	30.57 ± 1.32	32.85 ± 4.76	Nil
3	Hexane	NI^b	NI^b	NI^b	NI^b	NI^b	Nil
4	Benzene	43.13 ± 7.67	54.9 ± 9.31	56.86 ± 10.19	70.58 ± 4.76	78.43 ± 0.00**	163.01 ± 85.35
5	Dichloromethane	NI^b	NI^b	NI^b	2.91 ± 0	4.49 ± 1.36	Nil
6	Chloroform	24.68 ± 8.5	39.28 ± 0	45.14 ± 2.71	47.56 ± 0.99	56.78 ± 2.13**	375 ± 17.170
7	Ethyl acetate	15.332 ± 2.03	23.06 ± 4.75	30.39 ± 5.71	32.24 ± 1.58	37.74 ± 4.19	Nil
8	Acetone	12.87 ± 2.5	13.61 ± 2.38	19.51 ± 1.27	23.21 ± 3.38	29.11 ± 3.83	Nil
9	Methanol	NI^b	NI^b	1.79 ± 1.27	2.53 ± 0.004	16.44 ± 3.43	Nil
10	Water	NI^b	NI^b	NI^b	NI^b	NI^b	Nil

^aResults were expressed as mean ± SD (𝑛 = 3).
^bNI: no inhibition.
* 𝑃 < 0.05.
** 𝑃 < 0.01.