- About this Journal ·
- Abstracting and Indexing ·
- Aims and Scope ·
- Annual Issues ·
- Article Processing Charges ·
- Articles in Press ·
- Author Guidelines ·
- Bibliographic Information ·
- Citations to this Journal ·
- Contact Information ·
- Editorial Board ·
- Editorial Workflow ·
- Free eTOC Alerts ·
- Publication Ethics ·
- Reviewers Acknowledgment ·
- Submit a Manuscript ·
- Subscription Information ·
- Table of Contents
Evidence-Based Complementary and Alternative Medicine
Volume 2012 (2012), Article ID 506214, 8 pages
Cardioprotective Effects of 20(S)-Ginsenoside Rh2 against Doxorubicin-Induced Cardiotoxicity In Vitro and In Vivo
1Department of Pharmacology, School of Pharmacy, Yantai University, Yantai 264005, China
2State Key Laboratory of Long-Acting and Targeting Drug Delivery Technologies, Luye Pharma Group Ltd., Yantai 264003, China
Received 27 May 2012; Revised 23 August 2012; Accepted 13 September 2012
Academic Editor: Seung-Heon Hong
Copyright © 2012 Hongbo Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- G. Minotti, P. Menna, E. Salvatorelli, G. Cairo, and L. Gianni, “Anthracyclines: molecular advances and pharmacologie developments in antitumor activity and cardiotoxicity,” Pharmacological Reviews, vol. 56, no. 2, pp. 185–229, 2004.
- J. M. Scott, A. Khakoo, J. R. Mackey, M. J. Haykowsky, P. S. Douglas, and L. W. Jones, “Modulation of anthracycline-induced cardiotoxicity by aerobic exercise in breast cancer: current evidence and underlying mechanisms,” Circulation, vol. 124, no. 5, pp. 642–650, 2011.
- L. Li, Q. Lu, Y. Shen, and X. Hu, “Schisandrin B enhances doxorubicin-induced apoptosis of cancer cells but not normal cells,” Biochemical Pharmacology, vol. 71, no. 5, pp. 584–595, 2006.
- S. Arunachalam, S. Y. Kim, S. H. Lee et al., “Davallialactone protects against adriamycin-induced cardiotoxicity in vitro and in vivo,” Journal of Natural Medicines, vol. 66, no. 1, pp. 149–157, 2012.
- R. D. Olson, P. S. Mushlin, D. E. Brenner et al., “Doxorubicin cardiotoxicity may be caused by its metabolite, doxorubicinol,” Proceedings of the National Academy of Sciences of the United States of America, vol. 85, no. 10, pp. 3585–3589, 1988.
- N. Li, Q. Pan, W. Han, Z. Liu, and X. Hu, “Schisandrin B prevents doxorubicin-induced cardiotoxicity via enhancing glutathione redox cycling,” Clinical Cancer Research, vol. 13, no. 22, pp. 6753–6760, 2007.
- W. Zhu, M. H. Soonpaa, H. Chen et al., “Acute doxorubicin cardiotoxicity is associated with p53-induced inhibition of the mammalian target of rapamycin pathway,” Circulation, vol. 119, no. 1, pp. 99–106, 2009.
- K. Li, R. Y. T. Sung, Z. H. Wei et al., “Thrombopoietin protects against in vitro and in vivo cardiotoxicity induced by doxorubicin,” Circulation, vol. 113, no. 18, pp. 2211–2220, 2006.
- A. R. Imondi, P. Della Torre, G. Mazué et al., “Dose-response relationship of dexrazoxane for prevention of doxorubicin- induced cardiotoxicity in mice, rats, and dogs,” Cancer Research, vol. 56, no. 18, pp. 4200–4204, 1996.
- N. Siveski-Iliskovic, N. Kaul, and P. K. Singal, “Probucol promotes endogenous antioxidants and provides protection against adriamycin-induced cardiomyopathy in rats,” Circulation, vol. 89, no. 6, pp. 2829–2835, 1994.
- J. Xiao, G. B. Sun, B. Sun et al., “Kaempferol protects against doxorubicin-induced cardiotoxicity in vivo and in vitro,” Toxicology, vol. 292, no. 1, pp. 53–62, 2012.
- M. Karmazyn, M. Moey, and X. T. Gan, “Therapeutic potential of ginseng in the management of cardiovascular disorders,” Drugs, vol. 71, no. 15, pp. 1989–2008, 2011.
- A. S. Attele, J. A. Wu, and C. S. Yuan, “Ginseng pharmacology: multiple constituents and multiple actions,” Biochemical Pharmacology, vol. 58, no. 11, pp. 1685–1693, 1999.
- D. Schibilsky, F. Beyersdorf, and U. Goebel, “Amelioration of rat cardiac cold ischemia/reperfusion injury with inhaled hydrogen or carbon monoxide, or both,” Journal of Heart and Lung Transplantation, vol. 29, no. 12, p. 1442, 2010.
- V. V. Kupriyanov, B. Xiang, J. Sun, and O. Jilkina, “The effects of drugs modulating K+ transport on Rb+ uptake and distribution in pig hearts following regional ischemia: 87Rb MRI study,” NMR in Biomedicine, vol. 15, no. 5, pp. 348–355, 2002.
- D. Zhu, L. Wu, C. R. Li et al., “Ginsenoside Rg1 protects rat cardiomyocyte from hypoxia/reoxygenation oxidative injury via antioxidant and intracellular calcium homeostasis,” Journal of Cellular Biochemistry, vol. 108, no. 1, pp. 117–124, 2009.
- J. Zhang, F. Zhou, X. Wu et al., “Cellular pharmacokinetic mechanisms of adriamycin resistance and its modulation by 20(S)-ginsenoside Rh2 in MCF-7/Adr cells,” British Journal of Pharmacology, vol. 165, no. 1, pp. 120–134, 2012.
- B. Li, J. Zhao, C. Z. Wang et al., “Ginsenoside Rh2 induces apoptosis and paraptosis-like cell death in colorectal cancer cells through activation of p53,” Cancer Letters, vol. 301, no. 2, pp. 185–192, 2011.
- E. K. Park, E. J. Lee, S. H. Lee et al., “Induction of apoptosis by the ginsenoside Rh2 by internalization of lipid rafts and caveolae and inactivation of Akt,” British Journal of Pharmacology, vol. 160, no. 5, pp. 1212–1223, 2010.
- E. K. Park, M. K. Choo, J. K. Oh, J. H. Ryu, and D. H. Kim, “Ginsenoside Rh2 reduces ischemic brain injury in rats,” Biological and Pharmaceutical Bulletin, vol. 27, no. 3, pp. 433–436, 2004.
- H. Wang, H. Li, M. Zuo et al., “Lx2-32c, a novel taxane and its antitumor activities in vitro and in vivo,” Cancer Letters, vol. 268, no. 1, pp. 89–97, 2008.
- M. Rajadurai and P. Stanely Mainzen Prince, “Preventive effect of naringin on cardiac markers, electrocardiographic patterns and lysosomal hydrolases in normal and isoproterenol-induced myocardial infarction in Wistar rats,” Toxicology, vol. 230, no. 2-3, pp. 178–188, 2007.
- X. Sun, Z. Zhou, and Y. J. Kang, “Attenuation of doxorubicin chronic toxicity in metallothionein-overexpressing transgenic mouse heart,” Cancer Research, vol. 61, no. 8, pp. 3382–3387, 2001.
- R. Shi, C. C. Huang, R. S. Aronstam, N. Ercal, A. Martin, and Y. W. Huang, “N-acetylcysteine amide decreases oxidative stress but not cell death induced by doxorubicin in H9c2 cardiomyocytes,” BMC Pharmacology, vol. 9, p. 7, 2009.
- K. Hellmann, “Overview and historical development of dexrazoxane,” Seminars in Oncology, vol. 25, no. 4, supplement 10, pp. 48–54, 1998.