Gastric Ulcers in Middle-Aged Rats: The Healing Effect of Essential Oil from Citrus aurantium L. (Rutaceae)

Table 1

Effect of 14-day treatment with essential oil (OEC) from Citrus aurantium (250 mg/kg) on healing the acetic acid-induced ulcer in the stomachs of middle-aged rats.

Treatment (p.o.)	Dose (mg/kg)	Macroscopic analyses		Histological analyses
		Lesion area; (mm^2)	Curative ratio; (%)	Regeneration area; (𝜇m)	Curative ratio; (%)
Negative control	—	1.67 ± 0.42	—	256.07 ± 20.67	—
Positive control	100	1.29 ± 0.50	22.75	375.00 ± 33.21*	46.44
OEC	250	0.40 ± 0.18*	76.05	407.87 ± 28.48**	59.28

(𝑛=14-15). Results are mean ± SEM. ANOVA followed by Dunnett’s test. *P < 0.05; **P < 0.01.