Table 3: Evaluation of toxicity in middle-aged rats of the essential oil (OEC) obtained from peels of Citrus aurantium after 14 consecutive days of treatment.

Treatment
(p.o.)
Control
(10 mL/kg)
Cimetidine
(100 mg/kg)
OEC
(250 mg/kg)

Weight
(arcosine)
Kidney0.52 ± 0.040.51 ± 0.150.57 ± 0.05*
Lungs0.27 ± 0.190.33 ± 0.140.30 ± 0.16
Liver2.03 ± 0.142.07 ± 0.61*2.32 ± 0.20**
Heart0.27 ± 0.050.28 ± 0.030.28 ± 0.06
Spleen0.14 ± 0.030.16 ± 0.030.15 ± 0.03

BiochemistryUrea (mg/dL)30.57 ± 4.2934.13 ± 6.4428.47 ± 3.40
Creatinine (mg/dL)0.76 ± 0.130.71 ± 0.080.75 ± 0.12
AST (UI/L)165.46 ± 30.59180.73 ± 18.10173.36 ± 33.23
ALT (UI/I)38.42 ± 4.3235.80 ± 6.3534.13 ± 5.87
Glucose (UI/L)79.57 ± 9.7477.80 ± 9.4976.87 ± 9.69

Results are mean ± SEM. ANOVA followed by Dunnett’s test. ( -15), *P < 0.05, and**P < 0.01.