A Systems Biology Approach to Uncovering Pharmacological Synergy in Herbal Medicines with Applications to Cardiovascular Disease
Figure 2
Drug-target interaction networks bioactive molecules from Radix Salviae Miltiorrhiza (RSM), Radix Astragali Mongolici (RAM), Radix Puerariae lobatae (RPL), and Radix Ophiopogonis Japonici (ROJ). (a) 40 bioactive compounds (blue circles) from RSM and 28 ones from RAM (green circles) predicted to have 23 potential protein targets (squares). The black squares (17) are the common targets of both herbs. The blue (4) and green (2) squares are the specific targets of RSM and RAM, respectively. (b) 40 bioactive compounds (blue circles) from RSM and 11 ones from RPL (red circles) predicted to have 22 potential protein targets (squares). The black squares (12) are the common targets of both herbs. The blue (9) and red (1) squares are the specific targets of RSM and RAM, respectively. (c) 40 bioactive compounds (blue circles) from RSM and 17 ones from ROJ (yellow circles) predicted to have 24 potential protein targets (squares). The black squares (14) are the common targets of both herbs. The blue (7) and yellow (3) squares are the specific targets of RSM and RAM, respectively.
