Evidence-Based Complementary and Alternative Medicine / 2012 / Article / Tab 1

Research Article

A Systems Biology Approach to Uncovering Pharmacological Synergy in Herbal Medicines with Applications to Cardiovascular Disease

Table 1

118 bioactive compounds from four herbs RSM, RAM, RPL, and ROJ and corresponding predicted oral bioavailability (OB), and drug-likeness (DL).

NO.CompoundDLOBHerbs*

M161ophiogenin0.76100.00ROJ
M306przewalskin b0.44100.00RSM
M476dimethyl-4,4′-dimethoxy-5,6,5′,6′-mdimethylene-dioxybiphenyl-2,2′-dicarboxylate0.67100.00RAM
M4657,2′-dihydroxy-3′,4′-dimethoxyisoflavone-7-O-β-D-glucoside0.8699.41RAM
M6tuberosin0.7695.05RPL
M1965-hydroxy-7,8-dimethoxy-6-methyl-3-(3′,4′-dihydroxybenzyl)chroman-4-one0.4193.42ROJ
M521Calycosin0.2488.9RAM
M2674-hydroxy-1-vinylcarboxy-7-(3,4-dihydroxyphenyl)benzo-β-furan0.3188.57RSM
M4624′-O-beta-Glucopyranosyl-5-O-Methylvisamminol0.8183.95RAM
M204N-[β-hydroxy-β-(4-hydroxy)phenyl]ethyl-4-hydroxy cinnamide0.2382.91ROJ
M4689,10-dimethoxypterocarpan-3-O-β-D-glucoside0.9281.91RAM
M411przewalskinone b0.2781.61RSM
M182ophiopogonanone F0.4581.49ROJ
M505astragaloside IV0.1581.32RAM
M493riboflavin0.581RAM
M480betulinic acid0.7878.63RAM
M510aglycon of astragaloside I0.277.02RAM
M433tanshindiol a0.4675.49RSM
M183ophiopogonanone G0.4675.41ROJ
M533aglycon of rhamnocitrin-3-O-glucoside0.2775.39RAM
M4615,4′-dihydroxy-3,7-dimethoxyflavone kumatakenin0.2975.36RAM
M550isoquercitrin0.7775.03RAM
M509astragaloside I0.1173.23RAM
M558-prenylgenistein0.3772.6RPL
M286formyltanshinone0.4272.34RSM
M390miltionone II0.4471.03RSM
M4677-O-methylisomucronulatol0.370.95RAM
M464aglycon of 5′-hydroxyiso-muronulatol-2′,5′-di-O-glucoside0.870.73RAM
M365epiRSMspiroketallactone0.3168.27RSM
M187ophiopogonone B0.3167.52ROJ
M559red sandalwood ene0.4866.61RAM
M492behenic acid0.2665.99RAM
M530kaempferol0.2465.98RAM
M507mucronulatol-7-O-glucoside0.8665.21RAM
M328tanshinol I0.5264.81RSM
M2006-aldehydoisoophiopogonone B0.3864.39ROJ
M406prolithospermic acid0.3164.3RSM
M523aglycon of calycosin-7-O-glucoside0.2464.29RAM
M501astragaloside III0.163.07RAM
M485aglycon of formononetin-7-glucoside0.2162.54RAM
M478γ-aminobutyric acid0.0162.12RAM
M439tanshinone VI0.361.7RSM
M213ophiopogonanone B0.359.58ROJ
M421salvianolic acid g0.6159.36RSM
M522calycosin-7-O-glucoside0.8158.36RAM
M327tanshinol II0.5658.29RSM
M1986-aldehydoisoophiopogonanone B0.3858.26ROJ
M4593,9-di-O-methylnissolin0.4857.75RAM
M512aglycon of astragaloside II0.2556.75RAM
M516rutin0.6856.65RAM
M376isotanshinone IIb0.4556.64RSM
M551aglycon of isoquercitrin0.2856.54RAM
M548-prenyldaidzein0.3356RPL
M351danshenspiroketallactone0.3155.99RSM
M311przewaquinone c0.455.83RSM
M373isocryptotanshinone0.3955.08RSM
M1976-aldehydo-7-methoxyl-isoophiopogonanone B0.4154.45ROJ
M326tanshinol a0.4154.27RSM
M546folic acid0.7153.33RAM
M325tanshinaldehyde0.4552.54RSM
M395neocryptotanshinone0.3252.54RSM
M343cryptotanshinone0.452.44RSM
M495aglycon of alexandrin0.7552.12RAM
M556biochain B0.2151.72RAM
M482aglycon of β-sitosterol-3-O-β-D-glucopyranoside daucosterol0.7550.29RAM
M377isotanshinone IIa0.450.02RSM
M389miltionone I 0.3249.68RSM
M506aglycon of astragaloside IV0.3249.67RAM
M356deoxyneocryptotanshinone0.2949.51RSM
M554isomucronulatol-7,2′-di-O-glucosiole0.6249.32RAM
M324aglycon of tannin0.2649.23RSM
M1(Z,Z,Z)-8,11,14-eicosatrienoic acid0.248.76RPL
M469aglycon of 9,10-dimethoxypterocarpan-3-O-β-D- glucoside0.4247.86RAM
M96daidzein-4′,7-diglucoside0.6747.27RPL
M348danshexinkum b0.2646.79RSM
M2706-O-syringyl-8-O-acetyl shanzhiside methyl ester0.7146.69RSM
M532rhamnocitrin-3-O-glucoside0.7645.82RAM
M363′-methoxydaidzin0.8145.13RPL
M2643α-hydroxytanshinone IIa0.4445.1RSM
M384manool0.245.06RSM
M359dihydrotanshinone I0.3645.04RSM
M393miltirone II 0.2444.95RSM
M477sitosterol0.7844.72RAM
M430stigmasterol0.7643.83RSM
M319sclareol0.2143.67RSM
M445 1-dehydrotanshinone0.443.67RSM
M518chlorogenic acid0.3343.43RAM
M357dihydroisotanshinone I0.3643.39RSM
M435tanshindiol c0.4542.87RSM
M434tanshindiol b0.4542.68RSM
M558lupenone0.7842.39RAM
M2653β-hydroxytanshinone IIa0.4542.17RSM
M312przewaquinone d0.4541.31RSM
M1685,7-dihydroxy-6,8-dimethyl-3-(2′-hydroxy-3′,4′-methylenedioxybenzyl)chromone0.5341.14ROJ
M2582-isopropyl-8-methylphenanthrene-3,4-dione0.2341.06RSM
M511astragaloside II0.1340.87RAM
M489syringaresinol0.7240.79RAM
M91soyasapogenol C0.7740.74RPL
M1675,7,2′-trihydroxy-8-methyl-3-(3′,4′-methylenedioxyb-enzyl)chromone0.4940.63ROJ
M171methylophiopogonone B0.3440.52ROJ
M2501,2,5,6-tetrahydrotanshinone0.3640.5RSM
M517lariciresinol0.3840.27RAM
M170methylophiopogonone A0.4840.24ROJ
M520aglycon of ononin0.2138.22RAM
M23daidzein0.1938.19RPL
M414salvianic acid a0.0635.95RSM
M24formononetin0.2132.3RPL
M438tanshinone IIb0.4521.7RSM
M119ophiopogonin D0.0620.86ROJ
M203methylophiopogonanone A0.4819.1ROJ
M186ophiopogonone A0.4414.24ROJ
M496quercetin0.2813.18RAM
M64puerarin0.6912.92RPL
M1996-aldehydoisoophiopogonone A0.5312.6ROJ
M67daidzin0.739.83RPL
M68formononetin-7-O-b-D-glycoside-ononin0.788.62RPL
M323tannin0.037.3RSM
M235methylophiopogonanone B0.345.26ROJ

*RSM (Radix Salviae Miltiorrhiza), RAM (Radix Astragali Mongolici), RPL (Radix Puerariae lobatae), and ROJ (Radix Ophiopogonis Japonici).

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