Differential Association of Uncoupling Protein 2 Polymorphisms with Pattern Identification among Korean Stroke Patients: A Diagnostic System in Traditional Korean Medicine
Table 3
Allele and genotype distribution of the SNPs between the control group and each PI group.
Allele
SNP
Allele
Normal
QD
OR (952 CI)
D&P
OR (952 CI)
YD
OR (952 CI)
F&H
OR (952 CI)
G-1957A
G
784 (68.53)
543 (68.73)
0.983
0.8738
910 (70.87)
0.881
0.193
306 (68.92)
0.885
0.367
748 (72.06)
0.819
0.0628
A
360 (31.47)
247 (31.27)
(0.793–1.218)
374 (29.13)
(0.727–1.066)
138 (31.08)
(0.678–1.154)
290 (27.94)
(0.663–1.011)
G-866A
G
561 (50.45)
408 (51.78)
0.970
0.7647
689 (53.74)
0.866
0.1129
220 (49.33)
1.039
0.7603
552 (53.08)
0.870
0.1577
A
551(49.55)
380 (48.22)
(0.794–1.185)
593 (46.26)
(0.726–1.034)
226 (50.67)
(0.813–1.328)
488 (46.92)
(0.717–1.055)
A55V
G
598 (51.29)
409 (51.90)
0.967
0.7451
691 (54.15)
0.874
0.1306
227 (50.90)
1.033
0.7959
561 (54.15)
0.866
0.1418
A
568 (48.71)
379 (48.10)
(0.793–1.178)
585 (45.85)
(0.733–1.041)
219 (49.10)
(0.809–1.317)
475 (45.85)
(0.715–1.049)
Genotype
Model
SNP
Genotype
Normal
QD
OR (952 CI)
D&P
OR (952 CI)
YD
OR (952 CI)
F&H
OR (952 CI)
G-1957A
GG
261 (45.6)
191 (48.42)
0.892
0.426
321 (50.00)
0.824
0.131
110 (49.55)
0.757
0.116
270 (52.02)
0.702
0.012
GA + AA
311 (54.4)
204 (51.62)
(0.672–1.183)
321 (50.00)
(0.642–1.059)
112 (50.45)
(0.534–1.071)
249 (47.98)
(0.534–0.924)
Do
G-866A
GG
130 (23.4)
107 (27.22)
0.826
0.249
195 (30.42)
0.668
0.006
58 (26.01)
0.817
0.324
146 (28.08)
0.647
0.007
GA + AA
426 (76.6)
287 (72.82)
(0.596–1.144)
446 (69.58)
(0.501–0.890)
165 (73.99)
(0.548–1.220)
374 (71.92)
(0.472–0.886)
A55V
GG
142 (24.4)
109 (27.72)
0.814
0.207
198 (31.03)
0.694
0.01
62 (27.80)
0.771
0.194
154 (29.73)
0.653
0.007
GA + AA
441 (75.6)
285 (72.32)
(0.591–1.121)
440 (68.97)
(0.525–0.918)
161 (72.20)
(0.522–1.141)
364 (70.27)
(0.480–0.888)
G-1957A
GG + GA
523 (91.4)
352 (89.12)
1.273
0.32
589 (91.74)
0.927
0.738
196 (88.29)
1.213
0.513
478 (92.10)
1.049
0.847
AA
49 (8.6)
43 (10.92)
(0.791–2.05)
53 (8.26)
(0.595–1.444)
26 (11.71)
(0.680–2.166)
41 (7.90)
(0.644–1.710)
Re
G-866A
GG + GA
431 (77.5)
301 (76.42)
1.125
0.493
494 (77.07)
1.038
0.805
162 (72.65)
1.359
0.134
406 (78.08)
1.075
0.662
AA
125 (22.5)
93 (23.62)
(0.804–1.575)
147 (22.93)
(0.770–1.401)
61 (27.35)
(0.910–2.030)
114 (21.92)
(0.777–1.489)
A55V
GG+GA
456 (78.2)
300 (76.12)
1.135
0.455
493 (77.27)
1.029
0.853
165 (73.99)
1.204
0.367
407 (78.57)
0.937
0.695
AA
127 (21.8)
94 (23.92)
(0.814–1.584)
145 (22.73)
(0.764–1.385)
58 (26.01)
(0.805–1.801)
111 (21.43)
(0.677–1.297)
Odd ratios and values were calculated by binary logistic regression model after adjustment for sex, age, smoking, and drinking and compared to the normal group.
