Antioxidant and Protective Effects of Bupleurum falcatum on the L-Thyroxine-Induced Hyperthyroidism in Rats

Table 3

Liver lipid peroxidation and antioxidant defense systems in the LT4 and test materials-treatedrats.

Groups	Lipid peroxidation; (MDA, nM/mg protein)	Antioxidant defense system
		GSH (nM/mg protein)	SOD (U/mg protein)	Catalase (U/mg protein)
Controls
Intact	1.59±0.24	26.58±5.42	18.59±2.72	21.08±3.63
LT4	3.68±0.48^a	12.49±3.26^c	39.53±13.29^c	38.50±3.05^a
Reference
PTU 10 mg/kg	2.65±0.70^ab	19.43±1.76^de	23.33±2.90^ce	30.43±5.69^ab
BR treated
300 mg/kg	2.02±0.36^b	21.75±1.50^de	21.11±1.24^de	25.97±2.10^ab
150 mg/kg	2.62±0.38^ab	19.48±1.16^de	23.50±2.04^ce	30.04±2.57^ab
75 mg/kg	3.04±0.35^ab	17.77±2.20^ce	24.23±3.78^ce	33.15±3.24^ab

Values are expressed mean ± S.D. of eight rats. BR: aqueous Bupleuri Radix extracts; LT4: levothyroxine; PTU: propylthiouracil. ^a𝑃<0.01 as compared with intact control by LSD test; ^b𝑃<0.01 as compared with LT4 control by LSD test; ^c𝑃<0.01 and ^d𝑃<0.05 as compared with intact control by MW test; ^e𝑃<0.01 as compared with LT4 control by MW test.