Ameliorative Effects of Scopoletin from Crossostephium chinensis against Inflammation Pain and Its Mechanisms in Mice
Figure 4
Histological appearance of the mouse hind footpad after a subcutaneous injection with Carr stained with H&E stain at the 5th hour to reveal hemorrhage, edema, and inflammatory cell infiltration in control mice, Carr-treated mice demonstrating hemorrhage with moderately extravascular red blood cells and a large amount of inflammatory leukocyte mainly neutrophils infiltration in the subdermis interstitial tissue of mice, and mice given Indo (10 mg/kg) before Carr. Scopoletin significantly shows morphological alterations (100x) (a) and the numbers of neutrophils in each scope () compared to subcutaneous injection of Carr only (b). Each point represents theaverage valuefor three individual animals. ### as compared with the control. *** compared with Carr group. Scale bar = 200 μm.
