Involvement of Prohibitin Upregulation in Abrin-Triggered Apoptosis
Figure 3
Downregulation of prohibitin (PHB) delays abrin (ABR)-triggered cell apoptosis. (a) Downregulation of PHB expression with siRNA delays ABR-triggered cell apoptosis in Jurkat T cells. The cells were treated with 1 nM ABR for 18 h . The average ± SD is shown from separate experiments. ***. (b) Downregulation of PHB inhibits expression of Bax and activation of caspase-3 and poly(ADP-ribose) polymerase (PARP) 9 h after ABR treatment as shown by western blot analysis.
