Different Effects of Resveratrol on Dose-Related Doxorubicin-Induced Heart and Liver Toxicity

Table 5

Histopathological hepatic changes in animals exposed to doxorubicin (DOX) with or without resveratrol (RV).

	𝑛	Eosinophilic degeneration	Parenchymatous degeneration	Vacuolar degeneration	Cellular edema	Pycnotic nuclei of hepatocytes	Necrosis	Inflammatory infiltration
Control	8	0	2	0	0	0	0/0^a	0/1^b
1DOX	6	5	5	0	4	0	0/0	0/0
1DOX + RV	6	4	5	2	0	2	0/0	0/2
2DOX	6	5	6	3	2	3	0/0	0/1
2DOX + RV	6	3	3	2	3	0	0/0	0/2

A single animal may be represented more than once in the listing of individual histological changes.
^aMassive necrosis/changes limited to single hepatocytes.
^bMassive inflammatory infiltration/disseminate mononuclear cells between hepatocytes.