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Evidence-Based Complementary and Alternative Medicine
Volume 2012 (2012), Article ID 620384, 9 pages
Research Article

Inhibitory Activities of Zygophyllum album: A Natural Weight-Lowering Plant on Key Enzymes in High-Fat Diet-Fed Rats

1Laboratory of Animal Ecophysiology, Faculty of Sciences of Sfax, University of Sfax, P.O. Box 95, Sfax 3000, Tunisia
2Laboratory of Chemistry of Natural Products, Faculty of Sciences of Sfax, B.P. 1171, Sfax 3000, Tunisia
3Biotechnology High School of Sfax (ISBS), University of Sfax, P.O. Box 261, Sfax 3052, Tunisia
4Hematological and Clinical Biochemistry Laboratory, Hospital of Sidi Bouzid, Sidi Bouzid 9100, Tunisia

Received 13 May 2012; Accepted 13 August 2012

Academic Editor: David Mischoulon

Copyright © 2012 Kais Mnafgui et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Obesity is a serious health problem that increased risk for many complications, including diabetes and cardiovascular disease. The results showed EZA, which found rich in flavonoids and phenolic compounds, exhibited an inhibitory activity on pancreatic lipase in vitro with IC50 of 91.07 μg/mL. In vivo administration of this extract to HFD-rats lowered body weight and serum leptin level; and inhibited lipase activity of obese rats by 37% leading to notable decrease of T-Ch, TGs and LDL-c levels accompanied with an increase in HDL-c concentration in serum and liver of EZA treated HFD-rats. Moreover, the findings revealed that EZA helped to protect liver tissue from the appearance of fatty cysts. Interestingly, supplementation of EZA modulated key enzyme related to hypertension such as ACE by 36% in serum of HFD animals and improve some of serum electrolytes such as Na+, K+, Cl, Ca2+ and Mg2+. Moreover, EZA significantly protected the liver-kidney function by reverted back near to normal the values of the liver-kidney dysfunction indices AST&ALT, ALP, CPK and GGT activities, decreased T-Bili, creat, urea and uric acid rates. In conclusion, these results showed a strong antihypelipidemic effect of EZA which can delay the occurrence of dislipidemia and hypertension.