Research Article
Antibacterial Activities of Selected Cameroonian Plants and Their Synergistic Effects with Antibiotics against Bacteria Expressing MDR Phenotypes
Table 6
MIC of different antibiotics after the association of the extract of Garcinia kola seeds at MIC/2, MIC/5 against ten MDR bacteria strains.
| Antibiotics | Extract concentration | Bacterial strains, MIC (μg/mL) of antibiotics in the absence and presence of the extract | AG100 | AG100Atet | AG102 | CM64 | EA3 | EA27 | KP55 | KP63 | EA289 | PA124 |
| CIP | 0 MIC/2 MIC/5 | ≤0.5 ≤0.5 ≤0.5 | 128 64(2)S 64(2)S | 32 8(4)S 8(4)S | ≤0.5 ≤0.5 ≤0.5 | 256 128(2)S 128(2)S | ≤0.5 ≤0.5 ≤0.5 | 256 128(2)S 256(1)I | 128 32(4)S 128(1)I | 64 32(2)S 64(1)I | 32 <0.5 16(2)S | CHL | 0 MIC/2 MIC/5 | 4 4(1)I 4(1)I | >512 512(>1) 512(>1) | 128 16(8)S 32(4)S | 512 256(2)S 512(1)I | 512 512(1)I 512(1)I | 64 8(8)S 16(4)S | 32 32(1)I 32(1)I | 512 128(4)S 256(2)S | 512 128(4)S 256(2)S | 64 32(2)S 32(2) S | STR | 0 MIC/2 MIC/5 | 4 2(2)S 2(2)S | >512 >512 >512 | <0.5 <0.5 <0.5 | 512 256(2)S 512(1)I | >512 >512 >512 | 16 8(2)S 16(1)I | 16 8(2)S 16(1)I | 128 128(1)I 128(1)I | 16 8(2)S 16(1)I | >512 16(>32)S 128(>4)S | AMP | 0 MIC/2 MIC/5 | 32 8(4)S 32(1)I | >512 >512 >512 | 256 128(2)S 128(2)S | >512 >512 >512 | >512 >512 >512 | 64 64(1)I 64(1)I | >512 >512 >512 | >512 512 512 | >512 >512 >512 | >512 64(>8)S 256(>2)S | TET | 0 MIC/2 MIC/5 | 64 32(2)S 32(2)S | 256 128(2)S 128(2)S | 8 2(4)S 2(4)S | 128 64(2)S 64(2)S | 512 256(2)S 256(2)S | 8 2(4)S 4(2)S | 8 2(4)S 4(2)S | 16 4(4)S 16(1)I | 32 8(4)S 8(4)S | 8 4(2)S 8(1)I | CLX | 0 MIC/2 MIC/5 | 32 16(2)S 32(1)I | >512 >512 >512 | >512 512 512 | >512 >512 >512 | >512 >512 >512 | 128 32(4)S 128(1)I | >512 >512 >512 | >512 >512 >512 | >512 >512 >512 | >512 128(>4)S >512 | KAN | 0 MIC/2 MIC/5 | ≤4 ≤4 ≤4 | 512 32(16)S 256(2)S | 16 16(1)I 16(1)I | ≤4 ≤4 ≤4 | ≤4 ≤4 ≤4 | >512 512 >512 | 32 4(8)S 16(2)S | 512 256(2)S 512(1)I | 32 ≤4(>8)S 32(1) S | 128 16(8)S 64(2)S | ERY | 0 MIC/2 MIC/5 | 64 16(4)S 64(1)I | 512 32(16)S 512(1)I | 16 16(1)I 16(1)I | 256 16(16)S 32(8)S | 64 16(4)S 16(4)S | 8 4(2)S 8(1)I | 64 64(1)I 64(1)I | 128 16(8)S 32(4)S | 128 128(1)I 128(1)I | 256 32(8)S 256(1)I | NOR | 0 MIC/2 MIC/5 | 32 8(4)S 16(2)S | 512 128(4)S 256(2)S | 128 64(2)S 128(1)I | 16 4(4)S 8(2)S | 16 8(2)S 8(2)S | 32 8(4)S 32(1)I | 128 32(4)S 128(1)I | 64 8(8)S 16(4)S | 64 32(2)S 32(2)S | 256 256(1)I 256(1)I | FEP | 0 MIC/2 MIC/5 | 512 512(1)I 512(1)I | >512 512 (>1) 512(>1) | >512 >512 >512 | >512 256(>2)S 256(>2)S | >512 >512 >512 | >512 >512 >512 | >512 >512 >512 | 512 256(2)S 512(1)S | 512 512(1)I 512(1)I | >512 512(>1) 512(>1) |
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(): fold increase in MIC values of the antibiotics after association with plants extract; S: synergy; I: indifference; AMP: ampicillin; FEP: cefepime; CHL: chloramphenicol; KAN: kanamycin; NOR: norfloxacin; STR: streptomycin; TET: tetracycline; CIP: ciprofloxacin; CLX: cloxacillin; ERY: erythromycin.
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