Analysis of Flavonoids from Eugenia uniflora Leaves and Its Protective Effect against Murine Sepsis

Figure 1

HE-Bu obtained from Eugenia uniflora leaves protects against sepsis-induced lethality and inhibits myeloperoxidase activity (measured after 6 h postoperation). Mice (10 animals/group) were orally administered various doses of HE-Bu (75, 150 or 300 mg·kg⁻¹), vehicle (3% ethanol), or dexamethasone (0.5 mg·kg⁻¹ s.c.). MPO graph: values represent means ± SEM. ***𝑃<0.001, and **𝑃<0.01, indicated value versus CLP plus vehicle group; ^###𝑃<0.001, CLP plus vehicle versus sham. ANOVA followed by Bonferroni’s test. Survival graph: survival analyses were compared by a logrank test. These calculations were performed with SigmaStat v3.10 (Systat Software Inc, Richmond, CA, USA). The null hypothesis was rejected when 𝑃<0.05.

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