Analysis of Flavonoids from Eugenia uniflora Leaves and Its Protective Effect against Murine Sepsis

Figure 2

Effect of HE-Bu obtained from Eugenia uniflora upon TNF-α (a) and IL-1β (b) production in infected mice serum. The mice, except the sham group, received vehicle, HE-Bu 75, 150. and 300 mg·kg⁻¹ (p.o.) or dexamethasone (0.5 mg·kg⁻¹ s.c.), which were administered 1 h before CLP surgery, and the cytokines levels were evaluated 6 h after onset. Each group represents the mean ± SEM of four to five animals. *𝑃<0.05, **𝑃<0.01, and ***𝑃<0.001 indicated value versus CLP plus vehicle group; ^##𝑃<0.01 and ^###𝑃<0.001, CLP plus vehicle versus sham. ANOVA followed by Bonferroni’s test. A false-operated group (sham) was also provided for this test.

(a)

(b)