Classification of Traditional Chinese Medicine Syndromes in Patients with Chronic Hepatitis B by SELDI-Based ProteinChip Analysis

Table 3

Significantly different peaks between healthy controls and excess or deficiency syndromes.^a

m/z	Healthy controls	Excess or deficiency syndrome	Change^b	P value
Healthy control versus excess syndrome
1174	0.20±0.49	0.69±1.17	↑
2037	𝟏.𝟕𝟏±𝟎.𝟕𝟏	𝟑.𝟏𝟎±𝟐.𝟐𝟒	↑
2269	𝟎.𝟖𝟔±𝟎.𝟑𝟖	𝟏.𝟔𝟐±𝟏.𝟐𝟓	↑
2592	0.49±0.27	−0.04±0.34	↓
3203	2.38±1.22	0.13±0.42	↓
3408	1.71±0.80	0.21±0.51	↓
4104	𝟑𝟐.𝟎𝟕±𝟏𝟑.𝟔𝟔	𝟏𝟏.𝟏𝟏±𝟔.𝟒𝟑	↓
4187	11.66±4.61	4.08±3.33	↓
429	7.98±2.88	3.64±2.53	↓
4311	4.79±1.46	1.97±2.70	↓
5032	−0.05±0.33	0.48±0.56	↑
5497	𝟏.𝟕𝟓±𝟎.𝟕𝟗	𝟎.𝟑𝟕±𝟎.𝟑𝟗	↓
5650	𝟏𝟖.𝟎𝟗±𝟔.𝟓𝟎	𝟗.𝟏𝟎±𝟓.𝟒𝟔	↓
7027	2.10±0.75	3.33±1.97	↑
7587	1.19±0.45	2.07±1.43	↑
11732	𝟎.𝟓𝟐±𝟎.𝟐𝟔	𝟏.𝟎𝟒±𝟎.𝟔𝟖	↑
14070	0.55±0.23	0.98±0.65	↑
15167	1.95±1.45	4.50±4.42	↑
15354	0.49±0.43	1.22±1.24	↑
22862	𝟏.𝟎𝟗±𝟎.𝟔𝟑	𝟐.𝟑𝟏±𝟏.𝟒𝟕	↑
23481	𝟐.𝟐𝟓±𝟏.𝟑𝟔	𝟒.𝟕𝟖±𝟐.𝟔𝟓	↑
28118	1.72±0.65	2.31±1.02	↑
33516	0.13±0.28	0.37±0.68	↑
38571	0.04±0.02	0.08±0.08	↑
38814	0.04±0.02	0.08±0.08	↑
46804	𝟎.𝟎𝟑±𝟎.𝟎𝟑	𝟎.𝟎𝟗±𝟎.𝟎𝟖	↑
47818	0.02±0.01	0.04±0.04	↑
Healthy control versus deficiency syndrome
1074	0.49±0.48	0.13±0.37	↓
1210	1.89±1.42	2.64±1.02	↑
1216	6.03±3.50	9.26±3.39	↑
1261	21.14±9.18	29.16±10.80	↑
1440	0.79±1.03	1.36±0.95	↑
2003	1.97±1.04	4.32±2.74	↑
2018	6.92±3.50	13.81±7.86	↑
2037	𝟏.𝟕𝟏±𝟎.𝟖𝟏	𝟑.𝟔𝟐±𝟐.𝟓𝟏	↑
2269	𝟎.𝟖𝟔±𝟎.𝟒𝟕	𝟏.𝟗𝟑±𝟏.𝟎𝟖	↑
3331	3.78±2.69	6.43±3.33	↑
4104	𝟑𝟐.𝟎𝟕±𝟏𝟖.𝟕𝟐	𝟏𝟔.𝟎𝟏±𝟏𝟏.𝟎𝟏	↓
5260	0.80±1.44	1.96±1.79	↑
5346	9.05±13.75	21.53±15.00	↑
5497	𝟏.𝟕𝟓±𝟏.𝟑𝟕	𝟎.𝟒𝟗±𝟎.𝟓𝟎	↓
5558	0.97±1.40	1.85±1.32	↑
5650	𝟏𝟖.𝟎𝟗±𝟏𝟎.𝟒𝟑	𝟏𝟎.𝟑𝟗±𝟕.𝟔𝟕	↓
5919	23.56±16.61	40.84±22.76	↑
5947	2.98±3.47	6.79±5.24	↑
6128	4.83±5.95	9.72±6.92	↑
8176	2.82±2.70	4.31±2.73	↑
9723	0.37±0.31	0.83±0.51	↑
10292	1.17±0.98	2.40±1.22	↑
11732	𝟎.𝟓𝟐±𝟎.𝟑𝟔	𝟎.𝟗𝟎±𝟎.𝟒𝟐	↑
15009	0.07±0.09	0.60±1.86	↑
22572	0.30±0.23	0.93±1.18	↑
22862	𝟏.𝟎𝟗±𝟎.𝟔𝟏	𝟐.𝟑𝟗±𝟏.𝟑𝟓	↑
23481	𝟐.𝟐𝟓±𝟏.𝟓𝟑	𝟒.𝟕𝟒±𝟐.𝟔𝟐	↑
46804	𝟎.𝟎𝟑±𝟎.𝟎𝟐	𝟎.𝟎𝟖±𝟎.𝟎𝟔	↑

^aProtein peaks marked in bold were the common biomarkers for CHB disease. ^b “↑” and “↓” represent the protein was up- and downregulated in CHB patients compared with the control, respectively.