Review Article

Clinical Efficacy and Safety of Buyang Huanwu Decoction for Acute Ischemic Stroke: A Systematic Review and Meta-Analysis of 19 Randomized Controlled Trials

Table 3

Summary of GRADE on evidences of outcomes of Bu-yang Huan-wu decoction for acute ischemic stroke.

Quality assessmentNumber of patientsEffectQualityImportance
Number of studiesDesignRisk of biasInconsistencyIndirectnessImprecisionOther considerationsTrialControlRelative
(95% CI)
Absolute

Effective rate

17Randomized  trialsVery seriousNo serious inconsistencyNo serious indirectnessNo serious imprecisionReporting bias696/747 (93.2%)535/697 (76.8%) RR 1.18
(1.12 to 1.24)
138 more per 1000 (from 92 more to 184 more)○○○  very lowImportant
75%135 more per 1000 (from 90 more to 180 more)

Neurological deficit scores (Modified Edinburgh–Scandinavian Stroke Scale)

9Randomized trialsVery seriousNo serious inconsistencyNo serious indirectnessNo serious imprecisionReporting bias409377MD 4.65 lower (6.57 to 2.72 lower)○○○ very lowImportant

Neurological deficit scores (ESS)

1Randomized trialsVery seriousNo serious inconsistencyNo serious indirectnessNo serious imprecisionNone3333MD 7.99 higher (3.96 to 12.02 higher)○○ lowImportant