A Systematic Review of Xuezhikang, an Extract from Red Yeast Rice, for Coronary Heart Disease Complicated by Dyslipidemia

Table 5

Adverse Events.

Ads/ID	Comparison	Treatment group (𝑛/𝑁)	Control group (𝑛/𝑁)	RR	95% CI
Loss of followup
Guan 2010 [22]	Xuezhikang versus simvastatin	16 (72)	15 (64)	0.95	[0.51,1.76]
CCSPS 2005 [4]	Xuezhikang and conventional therapy versus placebo and conventional therapy	37 (2441)	28 (2429)	1.31	[0.81,2.14]
Ma and Teng 2005 [29]	Xuezhikang and conventional therapy versus conventional therapy	1 (29)	No report
Intestinal disturbance
Guan 2010 [22]	Xuezhikang versus simvastatin	5 (72)	2 (64)	2.22	[0.45,11.06]
Ma and Teng 2005 [29]	Xuezhikang and conventional therapy versus conventional therapy	2 (29)	No report
Wang et al. 2004 [6]	Xuezhikang and conventional therapy versus conventional therapy	2 (26)	No report
Jiang and Cai 2001 [25]	Xuezhikang and conventional therapy versus simvastatin and conventional therapy	0 (30)	1 (45)	0.49	[0.02,11.75]
Shang 2007 [31]	Xuezhikang and conventional therapy versus atorvastatin and conventional therapy	No report	1 (65)
Wang and Xiao 2000 [32]	Xuezhikang and aspirin versus inositol nicotinate and aspirin	5 (65)	2 (57)	2.19	[0.44,10.87]
Headache
Jiang and Cai 2001 [25]	Xuezhikang and conventional therapy versus simvastatin and conventional therapy	1 (30)	0 (45)	4.45	[0.19,105.77]
Dizziness
Guan 2010 [22]	Xuezhikang and conventional therapy versus simvastatin and conventional therapy	0 (72)	10 (64)	0.04	[0.00,0.71]
Jiang and Cai 2001 [25]	Xuezhikang and conventional therapy versus simvastatin and conventional therapy	1 (30)	1 (45)	1.5	[0.10,23.07]
		Overall (REM, I^2 = 72%)		0.26	[𝟎.𝟎𝟏,𝟏𝟎.𝟒𝟗]
Skin itech
Guan 2010 [22]	Xuezhikang versus simvastatin	0 (72)	3 (64)	0.13	[0.01,2.42]
Wang and Xiao 2000 [32]	Xuezhikang and aspirin versus inositol nicotinate and aspirin	0 (65)	3 (57)	0.13	[0.01,2.38]
Sexual dysfunction
CCSPS 2005 [4]	Xuezhikang and conventional therapy versus placebo and conventional therapy	0 (1996)	5 (1990)	0.09	[0.01,1.64]
High serum ALT
CCSPS 2005 [4]	Xuezhikang and conventional therapy versus placebo and conventional therapy	15 (2441)	22 (2429)	0.68	[0.35,1.30]
Lou et al. 2008 [28]	Xuezhikang and conventional therapy versus simvastatin and conventional therapy	No report	1 (41)
High serum CK
CCSPS 2005 [4]	Xuezhikang and conventional therapy versus placebo and conventional therapy	0 (2441)	3 (2429)	0.14	[0.01,2.75]
High serum CR
CCSPS 2005 [4]	Xuezhikang and conventional therapy versus placebo and conventional therapy	104 (2441)	89 (2429)	1.16	[0.88,1.53]
High BUN
CCSPS 2005 [4]	Xuezhikang and conventional therapy versus placebo and conventional therapy	124 (2441)	131 (2429)	0.94	[0.74,1.20]