Attenuation of TRPV1 and TRPV4 Expression and Function in Mouse Inflammatory Pain Models Using Electroacupuncture
Figure 1
Acupuncture effectively decreased nociceptive responses in Carra (carrageenan) (a and c) and CFA- (complete-Freund’s-adjuvant-) induced (b and d) inflammatory pain models. Mice from each inflammation model were tested for mechanical sensitivity with the electronic von Frey filament test (a and b) and thermal sensitivity with the radial heat test (c and d). The mice were tested before injection (Base) and on day 4 (D4). On day 4, mice were tested for inflammation-induced pain and the effect of EA (electroacupuncture) at ST36 and sham EA (EA-sham) was evaluated. For each model, four groups of mice were tested: Con (Control), Inflam (chemical-injected), EA (electroacupuncture), and EA-sham groups. compared with the baseline; for Inflam compared with EA-ST36 groups ( per group).
