Attenuation of TRPV1 and TRPV4 Expression and Function in Mouse Inflammatory Pain Models Using Electroacupuncture
Table 1
Electrophysiological analysis of action potential parameter, TRPV1, and TRPV4 current properties.
Con ()
CFA ()
EA ()
Resting membrane potential (mV)
−46.70 ± 1.72
−44.60 ± 1.42
−42.04 ± 2.41
Capacitance (pF)
35.39 ± 1.83
37.29 ± 1.84
37.93 ± 4.29
AP threshold (mV)
−19.93 ± 1.35
−25.04 ± 2.58**
−17.66 ± 2.86#
AP rheobase (pA)
483.03 ± 41.80
401.83 ± 22.92*
600.10 ± 58.79##
AP amplitude (mV)
78.35 ± 2.28
73.82 ± 3.31
74.79 ± 4.74
AP rise time (ms)
2.30 ± 0.11
2.07 ± 0.02*
2.49 ± 0.14##
AP fall time (ms)
6.36 ± 0.37
3.96 ± 0.39**
8.41 ± 2.28#
AHP (ms)
71.69 ± 8.24
60.22 ± 9.43
77.14 ± 10.14
TRPV1%
20.51
30
14.29
TRPV4%
17.95
33.33
17.85
TRPV1 amplitude (pA)
90.79 ± 12.99
189.53 ± 39.38*
67.74 ± 11.53#
TRPV4 amplitude (pA)
99.35 ± 14.54
374.24 ± 108.59*
129.48 ± 24.93#
*
P < 0.05 compared with the control group; **P < 0.01 compared with the control group; #P < 0.05 between the inflammation and EA groups; ##P < 0.01 between the inflammation and EA groups. Con: control; CFA: complete Freund’s adjuvant; EA: electroacupuncture; AP: action potential; AHP: afterhyperpolarization.
