A Herbal Composition of Semen Hoveniae, Radix Puerariae, and Fructus Schisandrae Shows Potent Protective Effects on Acute Alcoholic Intoxication in Rodent Models
Table 2
Effects of SRFE on serum ethanol and acetaldehyde concentrations in acutely inebriated rats.
Groups
Doses
Ethanol
Ethanol
Acetaldehyde
(g/kg)
(g/kg)
(h)
(g/L)
AUC (g·h/L)
(h)
(mg/L)
AUC (mg·h/L)
Model
—
4.50
2.94 ± 0.78
2.40 ± 0.31
8.12 ± 1.14
3.11 ± 0.73
73 ± 6
316 ± 38
SRFE
0.04
4.50
2.06 ± 0.76
3.55 ± 0.39*
12.89 ± 1.57*
2.61 ± 0.67
68 ± 6
332 ± 36
0.08
4.50
2.94 ± 0.78
1.52 ± 0.15*
5.38 ± 0.49*
1.28 ± 0.25*
53 ± 4*
226 ± 17
0.16
4.50
2.05 ± 0.53
1.35 ± 0.18**
4.81 ± 0.91*
1.50 ± 0.58
43 ± 5**
159 ± 16**
HWJZ
0.25
4.50
0.83 ± 0.17*
2.37 ± 0.35
8.08 ± 1.14
1.11 ± 0.23*
74 ± 10
265 ± 33
SRFE: Semen Hoveniae, Radix Puerariae, and Fructus Schisandrae extract; HWJZ: Hai-Wang-Jin-Zun tablet; : time to peak concentration; : peak concentration; AUC: area under the curve. Means ± S.E.M., . , versus model.
