A Herbal Composition of Semen Hoveniae, Radix Puerariae, and Fructus Schisandrae Shows Potent Protective Effects on Acute Alcoholic Intoxication in Rodent Models

Table 3

Effects of SRFE on ADH and ALDH levels in acutely inebriated rats.

Groups	Doses (g/kg)	Ethanol (g/kg)	Stomach		Small intestine		Liver
			ADH; (U/g prot)	ALDH; (𝜇mol/L)	ADH; (U/g prot)	ALDH; (𝜇mol/L)	ADH; (U/g prot)	ALDH; (𝜇mol/L)
Control	—	0.00	0.95 ± 0.03	0.39 ± 0.01	2.75 ± 0.20	1.65 ± 0.06	7.56 ± 0.33	6.31 ± 0.08
SRFE control	0.16	0.00	1.10 ± 0.05^#	0.42 ± 0.01	3.12 ± 0.14	1.73 ± 0.11	9.56 ± 0.34^##	8.10 ± 0.10^##
Model	—	4.50	0.85 ± 0.07	0.36 ± 0.02^#	2.49 ± 0.26	0.46 ± 0.08^##	8.87 ± 0.57	7.92 ± 0.33^##
SRFE	0.04	4.50	0.97 ± 0.05	0.38 ± 0.01	2.75 ± 0.27	0.45 ± 0.05	8.92 ± 0.45	7.91 ± 0.21
	0.08	4.50	0.97 ± 0.05	0.41± 0.02^*	2.91 ± 0.22	0.57 ± 0.10	9.29 ± 0.53	8.11 ± 0.28
	0.16	4.50	1.07± 0.05^*	0.41± 0.01^*	3.27 ± 0.22^*	1.19 ± 0.14^**	9.77 ± 0.35	8.27 ± 0.26
HWJZ	0.25	4.50	0.97 ± 0.06	0.36 ± 0.01	2.81 ± 0.22	0.80 ± 0.14	10.47 ± 0.50^*	9.95 ± 0.24^**

SRFE: Semen Hoveniae, Radix Puerariae, and Fructus Schisandrae extract; HWJZ: Hai-Wang-Jin-Zun tablet; ADH: ethanol dehydrogenase; ALDH: acetaldehyde dehydrogenase. Means ± S.E.M., 𝑛=9. ^#𝑃<0.05, ^##𝑃<0.01 versus control; ^∗𝑃<0.05, ^∗∗𝑃<0.01 versus model.