Brachystemma calycinum D. Don Effectively Reduces the Locomotor Disability in Dogs with Naturally Occurring Osteoarthritis: A Randomized Placebo-Controlled Trial

Table 2

Selected studies that reported statistically significant changes (i.e., improvement) in peak vertical force following different therapeutic approaches in dogs naturally afflicted by osteoarthritis.

Therapeutic approaches	Authors	Changes in peak vertical force	Trial duration
		(% BW)	(sample size)
Nonsteroidal anti-inflammatory drugs
Etodolac	Budsberg et al. [20]	2.3 (0.4)	8 days (34)
Carprofen	Moreau et al. [22]	2.4 [−3.4 to 17.0]	60 days (16)
Meloxicam	Moreau et al. [22]	4.7 [−4.9 to 92.2]	60 days (16)
Licofelone	Moreau et al. [15]	2.9 ± 1.7	28 days (13)
Carprofen	Hielm-Bjorkmanet al. [21]	3.2 [−8.2 to 11.8]	56 days (15)
Complementary and alternative medicine
Elk velvet antler	Moreau et al. [23]	2.4 ± 0.7	60 days (25)
Multiherbal preparation	E. Troncy (internal data)	2.6 (2.1)	56 days (13)
Homeopathic preparation	Hielm-Bjorkmanet al. [21]	2.3 [−3.4 to 10.2]	56 days (14)
Veterinary therapeutic diets
Omega-3 fatty acids	Roush et al. [26]	3.9 ± 1.3	90 days (22)
Green lipped mussel	Rialland et al. [24]	2.5 (4.2)	60 days (23)
Omega-3 fatty acids	Moreau et al. [25]	3.5 (6.8)	90 days (14)

% BW stands for percentage of body weight. Mean (standard deviation). Median (minimum to maximum). Mean ± standard error of the mean.