Table of Contents Author Guidelines Submit a Manuscript
Evidence-Based Complementary and Alternative Medicine
Volume 2012, Article ID 650718, 7 pages
http://dx.doi.org/10.1155/2012/650718
Research Article

Effect of a New Prokinetic Agent DA-9701 Formulated with Corydalis Tuber and Pharbitidis Semen on Cytochrome P450 and UDP-Glucuronosyltransferase Enzyme Activities in Human Liver Microsomes

1Drug Metabolism and Bioanalysis Laboratory, College of Pharmacy, The Catholic University of Korea, 43-1 Yeokgok 2-dong, Wonmi-gu, Gyeonggi-do, Bucheon, 420-743, Republic of Korea
2College of Pharmacy and Research Institute of Pharmaceutical Sciences, Kyungpook National University, Daegu 702-701, Republic of Korea
3Research Center, Dong-A Pharmaceutical Co., Yongin 446-905, Republic of Korea

Received 17 November 2011; Accepted 2 January 2012

Academic Editor: Alfredo Vannacci

Copyright © 2012 Hye Young Ji et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. H. B. El-Serag and N. J. Talley, “Systematic review: the prevalence and clinical course of functional dyspepsia,” Alimentary Pharmacology and Therapeutics, vol. 19, no. 6, pp. 643–654, 2004. View at Publisher · View at Google Scholar · View at Scopus
  2. G. E. Boeckxstaens, D. P. Hirsch, S. D. Kuiken, S. H. Heisterkamp, and G. N. J. Tytgat, “The proximal stomach and postprandial symptoms in functional dyspeptics,” The American Journal of Gastroenterology, vol. 97, no. 1, pp. 40–48, 2002. View at Publisher · View at Google Scholar · View at Scopus
  3. B. D. Maes, Y. F. Ghoos, M. I. Hiele, and P. J. Rutgeerts, “Gastric emptying rate of solids in patients with nonulcer dyspepsia,” Digestive Diseases and Sciences, vol. 42, no. 6, pp. 1158–1162, 1997. View at Publisher · View at Google Scholar · View at Scopus
  4. G. Sarnelli, P. Caenepeel, B. Geypens, J. Janssens, and J. Tack, “Symptoms associated with impaired gastric emptying of solids and liquids in functional dyspepsia,” The American Journal of Gastroenterology, vol. 98, no. 4, pp. 783–788, 2003. View at Publisher · View at Google Scholar · View at Scopus
  5. B. D. J. van den Elzen and G. E. E. Boeckxstaens, “Review article: a critical view on impaired accommodation as therapeutic target for functional dyspepsia,” Alimentary Pharmacology and Therapeutics, vol. 23, no. 11, pp. 1499–1510, 2006. View at Publisher · View at Google Scholar · View at Scopus
  6. S. Choi, J. J. Choi, J. Y. Jun et al., “Induction of pacemaker currents by DA-9701, a prokinetic agent, in interstitial cells of Cajal from murine small intestine,” Molecules and Cells, vol. 27, no. 3, pp. 307–312, 2009. View at Publisher · View at Google Scholar · View at Scopus
  7. E. R. Kim, B. H. Min, S. O. Lee, T. H. Lee, M. Son, and P. L. Rhee, “The effects of DA-9701, a novel prokinetic agent, on gastric accommodation in conscious dogs,” Journal of Gastroenterology and Hepatology. In press. View at Publisher · View at Google Scholar
  8. T. H. Lee, J. J. Choi, D. H. Kim et al., “Gastroprokinetic effects of DA-9701, a new prokinetic agent formulated with Pharbitis Semen and Corydalis Tuber,” Phytomedicine, vol. 15, no. 10, pp. 836–843, 2008. View at Publisher · View at Google Scholar · View at Scopus
  9. M. Kubo, H. Matsuda, K. Tokuoka, S. Ma, and H. Shiomoto, “Anti-inflammatory activities of methanolic extract and alkaloidal components from Corydalis tuber,” Biological and Pharmaceutical Bulletin, vol. 17, no. 2, pp. 262–265, 1994. View at Google Scholar · View at Scopus
  10. H. Matsuda, K. Tokuoka, J. Wu, T. Tanaka, and M. Kubo, “Inhibitory effects of methanolic extract from corydalis tuber against types I-IV allergic models,” Biological and Pharmaceutical Bulletin, vol. 18, no. 7, pp. 963–967, 1995. View at Google Scholar · View at Scopus
  11. C. S. Yuan, S. R. Mehendale, C. Z. Wang et al., “Effects of Corydalis yanhusuo and Angelicae dahuricae on cold pressor-induced pain in humans: a controlled trial,” Journal of Clinical Pharmacology, vol. 44, no. 11, pp. 1323–1327, 2004. View at Publisher · View at Google Scholar · View at Scopus
  12. T. H. Lee, K. H. Kim, S. O. Lee, K. R. Lee, M. Son, and M. Jin, “Tetrahydroberberine, an isoquinoline alkaloid isolated from corydalis tuber, enhances gastrointestinal motor function,” Journal of Pharmacology and Experimental Therapeutics, vol. 338, no. 3, pp. 917–924, 2011. View at Publisher · View at Google Scholar
  13. T. H. Lee, M. Son, and S. Y. Kim, “Effects of corydaline from corydalis tuber on gastric motor function in an animal model,” Biological and Pharmaceutical Bulletin, vol. 33, no. 6, pp. 958–962, 2010. View at Publisher · View at Google Scholar · View at Scopus
  14. M.-E. F. Mohamed and R. F. Frye, “Effects of herbal supplements on drug glucuronidationreview of clinical, animal, and in vitro studies,” Planta Medica, vol. 77, no. 4, pp. 311–321, 2011. View at Publisher · View at Google Scholar
  15. D. H. Na, H. Y. Ji, E. J. Park, M. S. Kim, K.-H. Liu, and H. S. Lee, “Evaluation of metabolism-mediated herb-drug interactions,” Archives of Pharmacal Research, vol. 34, no. 11, pp. 1829–1842, 2011. View at Publisher · View at Google Scholar
  16. S. F. Zhou, Z. W. Zhou, C. G. Li et al., “Identification of drugs that interact with herbs in drug development,” Drug Discovery Today, vol. 12, no. 15-16, pp. 664–673, 2007. View at Publisher · View at Google Scholar · View at Scopus
  17. S.-M. He, E. Chan, and S.-F. Zhou, “ADME properties of herbal medicines in humans: evidence, challenges andstrategies,” Current Pharmaceutical Design, vol. 17, no. 4, pp. 357–407, 2011. View at Publisher · View at Google Scholar
  18. S. M. He, A. K. Yang, X. T. Li, Y. M. Du, and S. F. Zhou, “Effects of herbal products on the metabolism and transport of anticancer agents,” Expert Opinion on Drug Metabolism and Toxicology, vol. 6, no. 10, pp. 1195–1213, 2010. View at Publisher · View at Google Scholar · View at Scopus
  19. H. Kim, K. B. Kim, H. Y. Ku et al., “Identification and characterization of potent CYP2B6 inhibitors in Woohwangcheongsimwon suspension, an herbal preparation used in the treatment and prevention of apoplexy in Korea and China,” Drug Metabolism and Disposition, vol. 36, no. 6, pp. 1010–1015, 2008. View at Publisher · View at Google Scholar · View at Scopus
  20. D. K. Sevior, J. Hokkanen, A. Tolonen et al., “Rapid screening of commercially available herbal products for the inhibition of major human hepatic cytochrome P450 enzymes using the N-in-one cocktail,” Xenobiotica, vol. 40, no. 4, pp. 245–254, 2010. View at Publisher · View at Google Scholar · View at Scopus
  21. X.-W. Chen, E. S. Serag, K. B. Sneed et al., “Clinical herbal interactions with conventional drugs: from molecules to maladies,” Current Medicinal Chemistry, vol. 18, no. 31, pp. 4836–4850, 2011. View at Publisher · View at Google Scholar
  22. H. Y. Ji, S. Y. Kim, D. K. Kim, J. H. Jeong, and H. S. Lee, “Effects of eupatilin and jaceosidin on cytochrome P450 enzyme activities in human liver microsomes,” Molecules, vol. 15, no. 9, pp. 6466–6474, 2010. View at Publisher · View at Google Scholar · View at Scopus
  23. H. Y. Ji, K. H. Liu, H. Lee et al., “Corydaline inhibits multiple cytochrome P450 and UDP-glucuronosyltransferase enzyme activities in human liver microsomes,” Molecules, vol. 16, no. 8, pp. 6591–6602, 2011. View at Publisher · View at Google Scholar
  24. J. Strandell, A. Neil, and G. Carlin, “An approach to the in vitro evaluation of potential for cytochrome P450 enzyme inhibition from herbals and other natural remedies,” Phytomedicine, vol. 11, no. 2-3, pp. 98–104, 2004. View at Publisher · View at Google Scholar · View at Scopus
  25. E. A. Dierks, K. R. Stams, H. K. Lim, G. Cornelius, H. Zhang, and S. E. Ball, “A method for the simultaneous evaluation of the activities of seven major human drug-metabolizing cytochrome P450s using an in vitro cocktail of probe substrates and fast gradient liquid chromatography tandem mass spectrometry,” Drug Metabolism and Disposition, vol. 29, no. 1, pp. 23–29, 2001. View at Google Scholar · View at Scopus
  26. M. J. Kim, H. Kim, I. J. Cha et al., “High-throughput screening of inhibitory potential of nine cytochrome P450 enzymes in vitro using liquid chromatography/tandem mass spectrometry,” Rapid Communications in Mass Spectrometry, vol. 19, no. 18, pp. 2651–2658, 2005. View at Publisher · View at Google Scholar · View at Scopus
  27. J. Zhou, T. S. Tracy, and R. P. Remmel, “Correlation between bilirubin glucuronidation and estradiol-3-gluronidation in the presence of model UDP-glucuronosyltransferase 1A1 substrates/inhibitors,” Drug Metabolism and Disposition, vol. 39, no. 2, pp. 322–329, 2011. View at Publisher · View at Google Scholar
  28. D. J. Newton, R. W. Wang, and A. Y. H. Lu, “Cytochrome P450 inhibitors: evaluation of specificities in the in vitro metabolism of therapeutic agents by human liver microsomes,” Drug Metabolism and Disposition, vol. 23, no. 1, pp. 154–158, 1995. View at Google Scholar · View at Scopus