Research Article
Effects of Berberine and Hwangryunhaedok-Tang on Oral Bioavailability and Pharmacokinetics of Ciprofloxacin in Rats
Figure 2
Plasma concentration-time curves of ciprofloxacin after intravenous and oral administration of ciprofloxacin to rats. On day 6, ciprofloxacin was administered after pretreatment of vehicle, berberine, or HR for 5 days. CFX alone and coadministration with berberine received distilled water (D.W.) instead of berberine or HR in the same period. CFX 10 alone (-∘-), CFX (i.v., 10 mg/kg) alone; CFX 20 alone (-●-), CFX (p.o., 20 mg/kg); CFX 20 + Co-BER 50 (-◆-), CFX (p.o., 20 mg/kg) + berberine (50 mg/kg); CFX 20 + Pre-HR (-▼-), CFX (p.o., 20 mg/kg) + pretreatment of HR 1.4 (1.4 g/kg/day); CFX 20 + Pre-BER 25 (-■-), CFX (p.o., 20 mg/kg) + pretreatment of berberine (25 mg/kg/day); CFX 20 + Pre-BER 50 (-▲-), CFX (p.o., 20 mg/kg) + pretreatment of berberine (50 mg/kg/day).
