Effects of Berberine and Hwangryunhaedok-Tang on Oral Bioavailability and Pharmacokinetics of Ciprofloxacin in Rats

Table 1

Summary of the experimental groups.

Groups	𝑛	Treatment^a
Group 1	4	CFX (i.v., 10 mg/kg)
Group 2	5	CFX (p.o., 20 mg/kg)
Group 3	5	CFX (p.o., 20 mg/kg) + berberine (p.o., 50 mg/kg)
Group 4	5	CFX (p.o., 20 mg/kg) + pretreatment of HR (p.o., 1.4 g/kg/day)
Group 5	5	CFX (p.o., 20 mg/kg) + pretreatment of berberine (p.o., 25 mg/kg/day)
Group 6	5	CFX (p.o., 20 mg/kg) + pretreatment of berberine (p.o., 50 mg/kg/day)

^aGroup 1, 2, and 3 received distilled water (D.W.) instead of berberine or HR in the same period. After 5 consecutive pretreatment of vehicle, berberine, or HR, ciprofloxacin was administered with or without berberine on day 6.