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Evidence-Based Complementary and Alternative Medicine
Volume 2012, Article ID 681207, 6 pages
Research Article

Study Bioprospecting of Medicinal Plant Extracts of the Semiarid Northeast: Contribution to the Control of Oral Microorganisms

1Laboratório de Desenvolvimento e Ensaio de Medicamentos, Universidade Estadual da Paraíba, 58.429-500 Campina Grande, PB, Brazil
2Programa de Pós-graduação em Odontologia, Universidade Estadual da Paraíba, 58.429-500 Campina Grande, PB, Brazil

Received 2 February 2012; Revised 10 April 2012; Accepted 12 April 2012

Academic Editor: Vincenzo De Feo

Copyright © 2012 Maria Suênia P. Silva et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Dental pathologies can be caused by plaque-forming bacteria and yeast, which reside in the oral cavity. The bacteria growing in dental plaque, a naturally occurring biofilm, display increased resistance to antimicrobial agents. The objective was the evaluation of a preclinical assay of medicinal plants of the semiarid region from the northeast against oral pathogenic microorganism, aiming at bioprospecting a new product. The selection of plant material for this study was based on the ethnobotanical data on the traditional use of plants from the semiarid region. The thirty extracts were subjected to the determination of antibiofilm activity against gram-positive, gram-negative bacteria and yeast. The hydroalcoholic extract which showed positive antibiofilm activity against most of the microorganisms tested in agar diffusion assay was further tested for the determination of minimum inhibitory concentration (MIC) and Bioassay with Artemia salina. Plant samples tested in this study exhibited good antibiofilm activity for the treatment of oral problems. The Schinopsis brasiliensis showed greater activity for Pseudomonas aeruginosa and Staphylococcus aureus, but toxicity against Artemia salina.