Inchingorei-san (TJ-117) and Artemisiae Capillaris Herba Induced Prolonged Survival of Fully Mismatched Cardiac Allografts and Generated Regulatory Cells in Mice
Figure 1
Graft survival of CBA mice given oral administration of Inchingorei-san (TJ-117) and its 6 components and histologic studies. (a) Recipients with C57BL/6 hearts were either untreated, given distilled water, or treated with 1 or 0.5 g/kg/day of TJ-117 from the day of transplantation until 7 days afterward. MST, median survival time; *P < 0.01 for difference between 2 groups. (b) Recipients with C57BL/6 hearts were given oral administration with each component of TJ-117. MST, median survival time; #P < 0.05 and *P < 0.01 for difference between 2 groups. (c) Histologic studies of harvested cardiac allografts stained with hematoxylin-eosin. The left pictures show samples obtained from mice treated with Artemisiae Capillaris Herba (ACH), and the right pictures show samples from untreated mice (magnification ×40 of upper two pictures and ×100 of lower two pictures).
