Morphologic and Pharmacological Investigations in the Epicatechin Gastroprotective Effect

Table 1

Histological scores (0–12) and immunoreactive areas (μm²) for HSP-70, SOD, and NO in rat stomachs (𝑛=7) with ethanol-induced gastric ulcers after treatment with vehicle, carbenoxolone (100 mg/kg), or epicatechin (50 mg/kg). The scores are represented by median (range), analyzed by ANOVA followed by Dunn, and compared to vehicle, ***𝑃<0.001. HSP-70, SOD, and NO are represented by the mean ± SEM, analyzed by ANOVA followed by Dunnett’s test, and compared to vehicle, **𝑃<0.01.

Analysis	Vehicle	Carbenoxolone	Epicatechin
Score	12 (11-12)	4 (2–7)***	3 (2-3)***
HSP-70	3718.93±479.00	1362.30 ± 244.50**	7861.07 ± 325.92**
SOD	15631.75±956.50	12933.21±581.75	26887.53 ± 971.40**
NO	10741.16±302.40	11892.80±324.72	13686.50 ± 581.96**