Zuonin B Inhibits Lipopolysaccharide-Induced Inflammation via Downregulation of the ERK1/2 and JNK Pathways in RAW264.7 Macrophages

Figure 1

Effects of Zuonin B on inhibition of LPS-induced nitric oxide (NO) and prostaglandin E₂ (PGE₂) production in RAW264.7 cells. Cells cultured in phenol red and serum-free media were pretreated with different concentrations of Zuonin B for 1 h and stimulated with a 1 μg/mL LPS for 24 h. (a) Structure of Zuonin B. (b) NO production. (c) Amount of PGE₂ release. (d) Cell viability. NC: untreated control cells; LPS: LPS only treatment. Data represent mean values of three experiments±SEM. *Significant difference from NC and ^#significant difference from LPS, 𝑃<0.05.

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