Effect of GCSB-5, a Herbal Formulation, on Monosodium Iodoacetate-Induced Osteoarthritis in Rats

Table 4

Effect of GCSB-5 on serum TNF-α, IL-1β, and IL-10 levels in MIA-induced osteoarthritic rats.

Group	TNF-α; (pg/mL)	IL-1β; (pg/mL)	IL-10; (pg/mL)
Control	30.0±4.5	29.1±3.7	27.8±0.6
MIA
Vehicle	85.4±6.6^b	99.5±11.2^b	60.4±7.2^b
GCSB-5
300 mg/kg	60.0±4.6^a,c	102.6±10.4^b	91.4±8.8^b,d
600 mg/kg	55.3±6.2^c	93.9±9.0^b	84.5±8.5^b,c
Diclofenac 5 mg/kg	50.1±4.0^d	49.5±7.5^d	86.1±9.2^b,c

The serum concentration of TNF-α, IL-1β, and IL-10 was determined using enzyme-linked immunosorbent assay. The results are presented as mean ± S.E.M. of 6 rats per group.
^a,bDenote significant differences (𝑃<0.05, 𝑃<0.01) compared with control group.
^c,dDenote significant differences (𝑃<0.05, 𝑃<0.01) compared with vehicle-treated MIA group.