Epimedium koreanum Extract and Its Constituent Icariin Improve Motor Dysfunction in Spinal Cord Injury

Figure 1

Effects of short treatment of the methanol extract of E. koreanum on hindlimb function in SCI mice. BMS score (a), the percentages of step event (b), and success rate (c) in ladder test were measured. SCI mice were administered the methanol extract of E. koreanum (100 mg/kg, p.o., closed circles, 7 mice, 14 hindlimbs, 𝑛=14 (a) and (b), 𝑛=7 (c)), or vehicle solution (open circles, 5 mice, 10 hindlimbs, 𝑛=10 (a) and (b), and 𝑛=5 (c)) for initial 3 days. Sham operated mice were also tested (open triangles, 7 mice, 14 hindlimbs, 𝑛=14 (a) and (b), and 𝑛=7 (c)). *Repeated measures two-way ANOVA followed by the post hoc Bonferroni test, 𝑃<0.05.

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