Epimedium koreanum Extract and Its Constituent Icariin Improve Motor Dysfunction in Spinal Cord Injury

Figure 3

Effects of short treatment of icariin on hindlimb function in SCI mice. BMS score (a), the percentages of step event (b), and success rate (c) in ladder test were measured. SCI mice were administered icariin (50 μmol/kg, p.o., closed circles, 7 mice, 14 hindlimbs, 𝑛=14 ((a) and (b)), and 𝑛=7 (c)) or vehicle solution (open circles, 5 mice, 10 hindlimbs, 𝑛=10 ((a) and (b)), and 𝑛=5 (c)) for initial 3 days. *Repeated measures two-way ANOVA followed by the post hoc Bonferroni test, 𝑃<0.05.

(a)

(b)

(c)