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Evidence-Based Complementary and Alternative Medicine
Volume 2012, Article ID 732404, 10 pages
http://dx.doi.org/10.1155/2012/732404
Research Article

Antileukemic Potential of Momordica charantia Seed Extracts on Human Myeloid Leukemic HL60 Cells

1Gene Regulation Laboratory, School of Biotechnology, Jawaharlal Nehru University, New Delhi 110 067, India
2Department of Zoology, University of Delhi, New Delhi 110 007, India

Received 7 January 2012; Revised 20 February 2012; Accepted 21 February 2012

Academic Editor: Raffaele Capasso

Copyright © 2012 Ramani Soundararajan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. O. Abdel-Wahab and R. L. Levine, “Recent advances in the treatment of acute myeloid leukemia,” F1000 Medicine Reports, vol. 2, no. 1, p. 55, 2010. View at Publisher · View at Google Scholar · View at Scopus
  2. A. Chopra and V. V. Doiphode, “Ayurvedic medicine: core concept, therapeutic principles, and current relevance,” Medical Clinics of North America, vol. 86, no. 1, pp. 75–89, 2002. View at Publisher · View at Google Scholar · View at Scopus
  3. B. B. Aggarwal, A. Bhardwaj, R. S. Aggarwal, N. P. Seeram, S. Shishodia, and Y. Takada, “Role of resveratrol in prevention and therapy of cancer: preclinical and clinical studies,” Anticancer Research A, vol. 24, no. 5, pp. 2783–2840, 2004. View at Google Scholar · View at Scopus
  4. B. B. Aggarwal, A. Kumar, and A. C. Bharti, “Anticancer potential of curcumin: preclinical and clinical studies,” Anticancer Research A, vol. 23, no. 1, pp. 363–398, 2003. View at Google Scholar · View at Scopus
  5. P. M. Venugopal and S. M. Prince, “Traditional medicines for modern times,” in Antidiabetic Plants, A. Sounyanath, Ed., CRC Press, New York, NY, USA, 2006. View at Google Scholar
  6. T. K. Behera, S. Behera, L. K. Bharathi, J. K. John, P. W. Simon, and J. E. Staub, “Bitter gourd: botany, horticulture and breeding,” in Horticultural Reviews, J. Janick, Ed., vol. 37, pp. 101–141, Wiley-VCH, Koln, Germany, 2010. View at Google Scholar
  7. T. B. Ng, W. K. Liu, S. F. Sze, and H. W. Yeung, “Action of α-momorcharin, a ribosome inactivating protein, on cultured tumor cell lines,” General Pharmacology, vol. 25, no. 1, pp. 75–77, 1994. View at Publisher · View at Google Scholar · View at Scopus
  8. S. Lee-Huang, P. L. Huang, H. C. Chen et al., “Anti-HIV and anti-tumor activities of recombinant MAP30 from bitter melon,” Gene, vol. 161, no. 2, pp. 151–156, 1995. View at Publisher · View at Google Scholar · View at Scopus
  9. H. Shi, M. Hiramatsu, M. Komatsu, and T. Kayama, “Antioxidant property of Fructus Momordicae extract,” Biochemistry and Molecular Biology International, vol. 40, no. 6, pp. 1111–1121, 1996. View at Google Scholar · View at Scopus
  10. J. K. Grover and S. P. Yadav, “Pharmacological actions and potential uses of Momordica charantia: a review,” Journal of Ethnopharmacology, vol. 93, no. 1, pp. 123–132, 2004. View at Publisher · View at Google Scholar · View at Scopus
  11. M. E. West, G. H. Sidrak, and S. P. Street, “The anti-growth properties of extracts from Momordica charantia L,” West Indian Medical Journal, vol. 20, no. 1, pp. 25–34, 1971. View at Google Scholar · View at Scopus
  12. T. Akihisa, N. Higo, H. Tokuda et al., “Cucurbitane-type triterpenoids from the fruits of Momordica charantia and their cancer chemopreventive effects,” Journal of Natural Products, vol. 70, no. 8, pp. 1233–1239, 2007. View at Publisher · View at Google Scholar · View at Scopus
  13. D. L. Vesely, W. R. Graves, and T. M. Lo, “Isolation of a guanylate cyclase inhibitor from the balsam pear (Momordica charantia abreviata),” Biochemical and Biophysical Research Communications, vol. 77, no. 4, pp. 1294–1299, 1977. View at Google Scholar
  14. A. J. Claflin, D. L. Vesely, and J. L. Hudson, “Inhibition of growth and guanylate cyclase activity of an undifferentiated prostate adenocarcinoma by an extract of the balsam pear (Momordica charantia abbreviata),” Proceedings of the National Academy of Sciences of the United States of America, vol. 75, no. 2, pp. 989–993, 1978. View at Google Scholar
  15. L. Barbieri, E. Lorenzoni, and F. Stirpe, “Inhibition of protein synthesis in vitro by a lectin from Momordica charantia and by other haemagglutinins,” Biochemical Journal, vol. 182, no. 2, pp. 633–635, 1979. View at Google Scholar · View at Scopus
  16. D. J. Takemoto, C. Dunford, and M. M. McMurray, “The cytotoxic and cytostatic effects of the bitter melon (Momordica charantia) on human lymphocytes,” Toxicon, vol. 20, no. 3, pp. 593–599, 1982. View at Google Scholar · View at Scopus
  17. C. Jilka, B. Strifler, and G. W. Fortner, “In vivo antitumor activity of the bitter melon (Momordica charantia),” Cancer Research, vol. 43, no. 11, pp. 5151–5155, 1983. View at Google Scholar · View at Scopus
  18. S. J. Collins, A. Bodner, R. Ting, and R. C. Gallo, “Induction of morphological and functional differentiation of human promyelocytic leukemia cells (HL-60) by compounds which induce differentiation of murine leukemia cells,” International Journal of Cancer, vol. 25, no. 2, pp. 213–218, 1980. View at Google Scholar · View at Scopus
  19. T. Shuto, T. Furuta, J. Cheung et al., “Increased responsiveness to TLR2 and TLR4 ligands during dimethylsulfoxide-induced neutrophil-like differentiation of HL-60 myeloid leukemia cells,” Leukemia Research, vol. 31, no. 12, pp. 1721–1728, 2007. View at Publisher · View at Google Scholar · View at Scopus
  20. K. W. Lee, H. J. Kim, Y. S. Lee et al., “Acteoside inhibits human promyelocytic HL-60 leukemia cell proliferation via inducing cell cycle arrest at G0/G1 phase and differentiation into monocyte,” Carcinogenesis, vol. 28, no. 9, pp. 1928–1936, 2007. View at Publisher · View at Google Scholar · View at Scopus
  21. R. C. Montenegro, M. C. de Vasconcellos, F. Silva Bezerra et al., “Pisosterol induces monocytic differentiation in HL-60 cells,” Toxicology in Vitro, vol. 21, no. 5, pp. 795–800, 2007. View at Publisher · View at Google Scholar · View at Scopus
  22. P. S. Sirohi, “Improvement in cucurbit vegetable,” Indian Horticulture, vol. 42, pp. 64–67, 1997. View at Google Scholar
  23. O. H. Lowry, N. J. Rosenbrough, A. L. Farr, and R. J. Randall, “Protein measurement with the Folin phenol reagent,” The Journal of biological chemistry, vol. 193, no. 1, pp. 265–275, 1951. View at Google Scholar · View at Scopus
  24. C. G. Yedjou, P. Moore, and P. B. Tchounwou, “Dose- and time-dependent response of human leukemia (HL-60) cells to arsenic trioxide treatment,” International Journal of Environmental Research and Public Health, vol. 3, no. 2, pp. 136–140, 2006. View at Publisher · View at Google Scholar · View at Scopus
  25. T. R. Breitman, S. E. Selonick, and S. J. Collins, “Induction of differentiation of the human promyelocytic leukemia cell line (HL-60) by retinoic acid,” Proceedings of the National Academy of Sciences of the United States of America, vol. 77, no. 5, pp. 2936–2940, 1980. View at Google Scholar · View at Scopus
  26. S. Ohri, D. Sharma, and A. Dixit, “Modulation of c-myc and c-fos gene expression in regenerating rat liver by 2-mercaptopropionylglycine,” Cell Biology International, vol. 26, no. 2, pp. 187–192, 2002. View at Publisher · View at Google Scholar · View at Scopus
  27. P. V. Alone, G. Malik, A. Krishnan, and L. C. Garg, “Deletion mutations in N-terminal α 1 helix render heat labile entertotoxin β subunit susceptible to degradation,” Proceedings of the National Academy of Sciences of the United States of America, vol. 104, pp. 16058–16061, 2007. View at Google Scholar
  28. D. Douer and H. P. Koeffler, “Retinoic acid. Inhibition of the clonal growth of human myeloid leukemia cells,” Journal of Clinical Investigation, vol. 69, no. 2, pp. 277–283, 1982. View at Google Scholar · View at Scopus
  29. H. Asou, M. Koike, E. Elstner et al., “19-nor vitamin-D analogs: a new class of potent inhibitors of proliferation and inducers of differentiation of human myeloid leukemia cell lines,” Blood, vol. 92, no. 7, pp. 2441–2449, 1998. View at Google Scholar · View at Scopus
  30. I. Molnár, T. Kute, M. C. Willingham, B. L. Powell, W. H. Dodge, and G. G. Schwartz, “19-Nor-1α, 25-dihydroxyvitamin D2 (paricalcitol): effects on clonal proliferation, differentiation, and apoptosis in human leukemic cell lines,” Journal of Cancer Research and Clinical Oncology, vol. 129, no. 1, pp. 35–42, 2003. View at Google Scholar · View at Scopus
  31. S. M. Kharbanda, M. L. Sherman, D. R. Spriggs, and D. W. Kufe, “Effects of tiazofurin on protooncogene expression during HL-60 cell differentiation,” Cancer Research, vol. 48, no. 21, pp. 5965–5968, 1988. View at Google Scholar · View at Scopus
  32. T. Watanabe, E. Sariban, T. Mitchell, and D. Kufe, “Human c-myc and N-ras expression during induction of HL-60 cellular differentiation,” Biochemical and Biophysical Research Communications, vol. 126, no. 3, pp. 999–1005, 1985. View at Google Scholar · View at Scopus
  33. H. M. Lachman and A. I. Skoultchi, “Expression of c-myc changes during differentiation of mouse erythroleukaemia cells,” Nature, vol. 310, no. 5978, pp. 592–594, 1984. View at Google Scholar · View at Scopus
  34. V. Sharma, D. K. Gupta, and J. P. Sharma, “Selective anti-proliferative effect of ocimum, ginger and bitter gourd on human cancer cells,” IJPI's Journal of Biotechnology and Biotherapeutics, vol. 2, pp. 12–16, 2011. View at Google Scholar
  35. Y. Jing, S. Nakajo, L. Xia et al., “Boswellic acid acetate induces differentiation and apoptosis in leukemia cell lines,” Leukemia Research, vol. 23, no. 1, pp. 43–50, 1999. View at Publisher · View at Google Scholar · View at Scopus
  36. S. Kawaii, Y. Tomono, E. Katase et al., “Acridones as inducers of HL-60 cell differentiation,” Leukemia Research, vol. 23, no. 3, pp. 263–269, 1999. View at Publisher · View at Google Scholar · View at Scopus
  37. A. W. Boyd and D. Metcalf, “Induction of differentiation in HL60 leukaemic cells: a cell cycle dependent all-or-none event,” Leukemia Research, vol. 8, no. 1, pp. 27–43, 1984. View at Google Scholar · View at Scopus
  38. H. Tanaka, E. Abe, and C. Miyaura, “1α,25-Dihydroxycholecalciferol and a human myeloid leukaemia cell line (HL-60). The presence of a cytosol receptor and induction of differentiation,” Biochemical Journal, vol. 204, no. 3, pp. 713–719, 1982. View at Google Scholar
  39. S. Radhika, S. K. Choudhary, L. C. Garg, and A. Dixit, “Induction of differentiation in murine erythroleukemia cells by 1α,25-dihydroxy vitamin D3,” Cancer Letters, vol. 90, no. 2, pp. 225–230, 1995. View at Publisher · View at Google Scholar · View at Scopus
  40. S. K. Choudhary, D. Sharma, and A. Dixit, “D,L-α-difluoromethylornithine, an irreversible inhibitor of ornithine decarboxylase, induces differentiation in MEL cells,” Cell Biology International, vol. 23, no. 7, pp. 489–495, 1999. View at Publisher · View at Google Scholar · View at Scopus
  41. R. Levenson and D. Housman, “Memory of MEL cells to a previous exposure to inducer,” Cell, vol. 17, no. 3, pp. 485–490, 1979. View at Google Scholar · View at Scopus
  42. S. H. Jeong, S. J. Koo, J. H. Choi et al., “Intermedeol isolated from the leaves of Ligularia fischeri var. spiciformis induces the differentiation of human acute promyeocytic leukemia HL-60 cells,” Planta Medica, vol. 68, no. 10, pp. 881–885, 2002. View at Publisher · View at Google Scholar · View at Scopus
  43. R. C. Hunt and L. M. Marshall, “Membrane protein redistribution during differentiation of cultured human erythroleukemic cells,” Molecular and Cellular Biology, vol. 1, no. 12, pp. 1150–1162, 1981. View at Google Scholar · View at Scopus
  44. E. F. Fang and T. B. Ng, “Bitter gourd (Momordica charantia) is a cornucopia of health: a review of its credited antidiabetic, Anti-HIV, and antitumor properties,” Current Molecular Medicine, vol. 11, no. 5, pp. 417–436, 2011. View at Publisher · View at Google Scholar
  45. E. F. Fang, C. Z. Y. Zhang, T. B. Ng et al., “Momordica charantia lectin, a type II ribosome inactivating protein, exhibits antitumor activity toward human nasopharyngeal carcinoma cells in vitro and in vivo,” Cancer Prevention Research, vol. 5, no. 1, pp. 109–121, 2012. View at Publisher · View at Google Scholar
  46. Y.-J. Xue, X.-H. Han, D. Chen, H. Huang, X.-Q. Li, and S.-H. Shao, “Effects of recombinant MAP30 on cell proliferation and apoptosis of human esophageal carcinoma EC-1.71 cells,” African Journal of Pharmacy and Pharmacology, vol. 5, no. 24, pp. 2680–2688, 2011. View at Publisher · View at Google Scholar
  47. H. P. Koeffler, “Induction of differentiation of human acute myelogenous leukemia cells: therapeutic implications,” Blood, vol. 62, no. 4, pp. 709–721, 1983. View at Google Scholar · View at Scopus
  48. R. Yazdanparast, M. Mahdavi, and M. A. Moosavi, “Induction of differentiation and apoptosis in three human leukemia cell lines by a new compound from Dendrostellera lessertii,” Acta Biochimica et Biophysica Sinica, vol. 38, no. 7, pp. 477–483, 2006. View at Publisher · View at Google Scholar · View at Scopus
  49. R. I. Bakare, O. A. Magbagbeola, A. I. Akinwande, and O. W. Okunowo, “Nutritional and chemical evaluation of Momordica charantia,” Journal of Medicinal Plant Research, vol. 4, no. 21, pp. 2189–2193, 2010. View at Google Scholar · View at Scopus
  50. M. Henriksson and B. Luscher, “Proteins of the myc network: essential regulators of cell growth and differentiation,” Advances in Cancer Research, vol. 68, pp. 110–182, 1996. View at Google Scholar · View at Scopus
  51. G. P. Studzinski, Z. S. Brelvi, S. C. Feldman, and R. A. Watt, “Participation of c-myc protein in DNA synthesis of human cells,” Science, vol. 234, no. 4775, pp. 467–470, 1986. View at Google Scholar · View at Scopus