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Evidence-Based Complementary and Alternative Medicine
Volume 2012 (2012), Article ID 732578, 10 pages
Caffeic Acid Phenethyl Ester Inhibits Oral Cancer Cell Metastasis by Regulating Matrix Metalloproteinase-2 and the Mitogen-Activated Protein Kinase Pathway
1School of Dentistry, Chung Shan Medical University, Taichung 40201, Taiwan
2Department of Dentistry, Chung Shan Medical University Hospital, Taichung 40201, Taiwan
3Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
4School of Medical Laboratory and Biotechnology, Chung Shan Medical University, Taichung 40201, Taiwan
5Department of Pathology, Changhua Christian Hospital, Changhua 50006, Taiwan
6Department of Medical Research, Chung Shan Medical University Hospital, Taichung 40201, Taiwan
7Institute of Oral Sciences, Chung Shan Medical University, Taichung 40201, Taiwan
Received 30 September 2012; Revised 10 November 2012; Accepted 19 November 2012
Academic Editor: Shrikant Anant
Copyright © 2012 Chih-Yu Peng et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- R. H. Spiro, A. E. Alfonso, H. W. Farr, and E. W. Strong, “Cervical node metastasis from epidermoid carcinoma of the oral cavity and oropharynx. A critical assessment of current staging,” American Journal of Surgery, vol. 128, no. 4, pp. 562–567, 1974.
- W. G. Stetler-Stevenson, L. A. Liotta, and D. E. Kleiner, “Extracellular matrix 6: role of matrix metalloproteinases in tumor invasion and metastasis,” FASEB Journal, vol. 7, no. 15, pp. 1434–1441, 1993.
- M. H. Chien, T. H. Ying, Y. S. Hsieh et al., “Dioscorea nipponica Makino inhibits migration and invasion of human oral cancer HSC-3 cells by transcriptional inhibition of matrix metalloproteinase-2 through modulation of CREB and AP-1 activity,” Food and Chemical Toxicology, vol. 50, pp. 558–566, 2012.
- S. F. Yang, M. K. Chen, Y. S. Hsieh et al., “Antimetastatic effects of Terminalia catappa L. on oral cancer via a down-regulation of metastasis-associated proteases,” Food and Chemical Toxicology, vol. 48, no. 4, pp. 1052–1058, 2010.
- M. Egeblad and Z. Werb, “New functions for the matrix metalloproteinases in cancer progression,” Nature Reviews Cancer, vol. 2, no. 3, pp. 161–174, 2002.
- A. R. Nelson, B. Fingleton, M. L. Rothenberg, and L. M. Matrisian, “Matrix metalloproteinases: biologic activity and clinical implications,” Journal of Clinical Oncology, vol. 18, no. 5, pp. 1135–1149, 2000.
- M. Björklund and E. Koivunen, “Gelatinase-mediated migration and invasion of cancer cells,” Biochimica et Biophysica Acta, vol. 1755, no. 1, pp. 37–69, 2005.
- S. M. Ranuncolo, E. Armanasco, C. Cresta, E. B. De Kier Joffe, and L. Puricelli, “Plasma MMP-9 (92 kDa-MMP) activity is useful in the follow-up and in the assessment of prognosis in breast cancer patients,” International Journal of Cancer, vol. 106, no. 5, pp. 745–751, 2003.
- M. Yokoyama, K. Ochi, M. Ichimura et al., “Matrix metalloproteinase-2 in pancreatic juice for diagnosis of pancreatic cancer,” Pancreas, vol. 24, no. 4, pp. 344–347, 2002.
- C. G. Sauer, A. Kappeler, M. Späth et al., “Expression and activity of matrix metalloproteinases-2 and -9 in serum, core needle biopsies and tissue specimens of prostate cancer patients,” Virchows Archiv, vol. 444, no. 6, pp. 518–526, 2004.
- G. Bugdayci, T. Kaplan, S. Sezer et al., “Matrix metalloproteinase-9 in broncho-alveolar lavage fluid of patients with non-small cell lung cancer,” Experimental Oncology, vol. 28, no. 2, pp. 169–171, 2006.
- S. D. Hong, S. P. Hong, J. I. Lee, and C. Y. Lim, “Expression of matrix metalloproteinase-2 and -9 in oral squamous cell carcinomas with regard to the metastatic potential,” Oral Oncology, vol. 36, no. 2, pp. 207–213, 2000.
- C. M. Coticchia, A. S. Curatolo, D. Zurakowski et al., “Urinary MMP-2 and MMP-9 predict the presence of ovarian cancer in women with normal CA125 levels,” Gynecologic Oncology, vol. 123, pp. 295–300, 2011.
- T. S. Wong, D. L. W. Kwong, J. S. T. Sham, W. I. Wei, Y. L. Kwong, and A. P. W. Yuen, “Clinicopathologic significance of plasma matrix metalloproteinase-2 and -9 levels in patients with undifferentiated nasopharyngeal carcinoma,” European Journal of Surgical Oncology, vol. 30, no. 5, pp. 560–564, 2004.
- N. Song, H. Sung, J. Y. Choi et al., “Preoperative serum levels of matrix metalloproteinase-2 (MMP-2) and survival of breast cancer among Korean women,” Cancer Epidemiology, Biomarkers & Prevention, vol. 21, pp. 1371–1380, 2012.
- J. W. Dobrowolski, S. B. Vohora, K. Sharma, S. A. Shah, S. A. H. Naqvi, and P. C. Dandiya, “Antibacterial, antifungal, antiamoebic, antiinflammatory and antipyretic studies on propolis bee products,” Journal of Ethnopharmacology, vol. 35, no. 1, pp. 77–82, 1991.
- P. Michaluart, J. L. Masferrer, A. M. Carothers et al., “Inhibitory effects of caffeic acid phenethyl ester on the activity and expression of cyclooxygenase-2 in human oral epithelial cells and in a rat model of inflammation,” Cancer Research, vol. 59, no. 10, pp. 2347–2352, 1999.
- O. K. Mirzoeva, P. Yaqoob, K. A. Knox, and P. C. Calder, “Inhibition of ICE-family cysteine proteases rescues murine lymphocytes from lipoxygenase inhibitor-induced apoptosis,” FEBS Letters, vol. 396, no. 2-3, pp. 266–270, 1996.
- Y. Lee, D. H. Shin, J. H. Kim et al., “Caffeic acid phenethyl ester-mediated Nrf2 activation and IκB kinase inhibition are involved in NFκB inhibitory effect: structural analysis for NFκB inhibition,” European Journal of Pharmacology, vol. 643, no. 1, pp. 21–28, 2010.
- W. K. Jung, D. Y. Lee, Y. H. Choi et al., “Caffeic acid phenethyl ester attenuates allergic airway inflammation and hyperresponsiveness in murine model of ovalbumin-induced asthma,” Life Sciences, vol. 82, no. 13-14, pp. 797–805, 2008.
- C. P. Chuu, H. P. Lin, M. F. Ciaccio et al., “Caffeic acid phenethyl ester suppresses the proliferation of human prostate cancer cells through inhibition of p70S6K and Akt signaling networks,” Cancer Prevention Research, vol. 5, pp. 788–797, 2012.
- Y. T. Lee, M. J. Don, P. S. Hung et al., “Cytotoxicity of phenolic acid phenethyl esters on oral cancer cells,” Cancer Letters, vol. 223, no. 1, pp. 19–25, 2005.
- M. Watabe, K. Hishikawa, A. Takayanagi, N. Shimizu, and T. Nakaki, “caffeic acid phenethyl ester induces apoptosis by inhibition of NFkappaB and activation of Fas in human breast cancer MCF-7 cells,” Journal of Biological Chemistry, vol. 279, no. 7, pp. 6017–6026, 2004.
- T. Ramqvist and T. Dalianis, “Oropharyngeal cancer epidemic and human papillomavirus,” Emerging Infectious Diseases, vol. 16, no. 11, pp. 1671–1677, 2010.
- L. M. Coussens and Z. Werb, “Matrix metalloproteinases and the development of cancer,” Chemistry and Biology, vol. 3, no. 11, pp. 895–904, 1996.
- M. H. Chien, C. W. Lin, C. W. Cheng, Y. C. Wen, and S. F. Yang, “Matrix metalloproteinase (MMP)-2 as a target for head and neck cancer therapy,” Expert Opinion on Therapeutic Targets. In press.
- A. Katayama, N. Bandoh, K. Kishibe et al., “Expressions of matrix metalloproteinases in early-stage oral squamous cell carcinoma as predictive indicators for tumor metastases and prognosis,” Clinical Cancer Research, vol. 10, no. 2, pp. 634–640, 2004.
- S. Kurahara, M. Shinohara, T. Ikebe et al., “Expression of MMPS, MT-MMP, and TIMPs in squamous cell carcinoma of the oral cavity: correlations with tumor invasion and metastasis,” Head & Neck, vol. 21, pp. 627–638, 1999.
- H. Qin, Y. Sun, and E. N. Benveniste, “The transcription factors Sp1, Sp3, and AP-2 are required for constitutive matrix metalloproteinase-2 gene expression in astroglioma cells,” Journal of Biological Chemistry, vol. 274, no. 41, pp. 29130–29137, 1999.
- P. A. M. Snoek-van Beurden and J. W. Von Den Hoff, “Zymographic techniques for the analysis of matrix metalloproteinases and their inhibitors,” BioTechniques, vol. 38, no. 1, pp. 73–83, 2005.
- R. K. Nuttall, C. J. Pennington, J. Taplin et al., “Elevated membrane-type matrix metalloproteinases in gliomas revealed by profiling proteases and inhibitors in human cancer cells,” Molecular Cancer Research, vol. 1, no. 5, pp. 333–345, 2003.
- S. Imren, D. B. Kohn, H. Shimada, L. Blavier, and Y. A. DeClerck, “Overexpression of tissue inhibitor of metalloproteinases-2 by retroviral-mediated gene transfer in vivo inhibits tumor growth and invasion,” Cancer Research, vol. 56, no. 13, pp. 2891–2895, 1996.
- P. Valente, G. Fassina, A. Melchiori et al., “TIMP-2 over-expression reduces invasion and angiogenesis and protects B16F10 melanoma cells from apoptosis,” International Journal of Cancer, vol. 75, pp. 246–253, 1998.
- D. W. Visscher, M. Höyhtyä, S. K. Ottosen et al., “Enhanced expression of tissue inhibitor of metalloproteinase-2 (TIMP-2) in the stroma of breast carcinomas correlates with tumor recurrence,” International Journal of Cancer, vol. 59, no. 3, pp. 339–344, 1994.
- P. N. Chen, Y. S. Hsieh, H. L. Chiou, and S. C. Chu, “Silibinin inhibits cell invasion through inactivation of both PI3K-Akt and MAPK signaling pathways,” Chemico-Biological Interactions, vol. 156, no. 2-3, pp. 141–150, 2005.
- Y. S. Hsieh, S. C. Chu, S. F. Yang, P. N. Chen, Y. C. Liu, and K. H. Lu, “Silibinin suppresses human osteosarcoma MG-63 cell invasion by inhibiting the ERK-dependent c-Jun/AP-1 induction of MMP-2,” Carcinogenesis, vol. 28, no. 5, pp. 977–987, 2007.
- C. J. Weng, C. F. Chau, Y. S. Hsieh, S. F. Yang, and G. C. Yen, “Lucidenic acid inhibits PMA-induced invasion of human hepatoma cells through inactivating MAPK/ERK signal transduction pathway and reducing binding activities of NF-κB and AP-1,” Carcinogenesis, vol. 29, no. 1, pp. 147–156, 2008.
- C. Huang, K. Jacobson, and M. D. Schaller, “MAP kinases and cell migration,” Journal of Cell Science, vol. 117, no. 20, pp. 4619–4628, 2004.
- Z. Huang, D. P. Yan, and B. X. Ge, “JNK regulates cell migration through promotion of tyrosine phosphorylation of paxillin,” Cellular Signalling, vol. 20, no. 11, pp. 2002–2012, 2008.
- O. Fromigué, Z. Hamidouche, and P. J. Marie, “Blockade of the RhoA-JNK-c-Jun-MMP2 cascade by atorvastatin reduces osteosarcoma cell invasion,” Journal of Biological Chemistry, vol. 283, no. 45, pp. 30549–30556, 2008.
- J. Zhong, M. M. C. Gencay, L. Bubendorf et al., “ERK1/2 and p38 MAP kinase control MMP-2, MT1-MMP, and TIMP action and affect cell migration: a comparison between mesothelioma and mesothelial cells,” Journal of Cellular Physiology, vol. 207, no. 2, pp. 540–552, 2006.
- B. Kumar, S. Koul, J. Petersen et al., “p38 Mitogen-activated protein kinase-driven MAPKAPK2 regulates invasion of bladder cancer by modulation of MMP-2 and MMP-9 activity,” Cancer Research, vol. 70, no. 2, pp. 832–841, 2010.
- T. Tian, K. J. Nan, H. Guo et al., “PTEN inhibits the migration and invasion of HepG2 cells by coordinately decreasing MMP expression via the PI3K/Akt pathway,” Oncology Reports, vol. 23, no. 6, pp. 1593–1600, 2010.